SLC28A3
Summary: Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 28 member 3 | MIM:608269 | Ensembl:ENSG00000197506 | HGNC:HGNC:16484 | PA426 | 9q21.32-q21.33 |
GO terms in SLC28A3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | IEA | GO:0015855 | pyrimidine nucleobase transport |
| BP | IBA | GO:0015860 | purine nucleoside transmembrane transport |
| BP | IEA | GO:0015860 | purine nucleoside transmembrane transport |
| BP | IBA | GO:0015864 | pyrimidine nucleoside transport |
| BP | IEA | GO:0035725 | sodium ion transmembrane transport |
| BP | IEA | GO:0072531 | pyrimidine-containing compound transmembrane transport |
| BP | IBA | GO:1901642 | nucleoside transmembrane transport |
| BP | IEA | GO:1904823 | purine nucleobase transmembrane transport |
| MF | IBA | GO:0005337 | nucleoside transmembrane transporter activity |
| MF | IBA | GO:0005415 | nucleoside:sodium symporter activity |
| MF | TAS | GO:0005415 | nucleoside:sodium symporter activity |
| MF | IBA | GO:0015389 | pyrimidine- and adenine-specific:sodium symporter activity |
| MF | IBA | GO:0015390 | purine-specific nucleoside:sodium symporter activity |
Gene expression in normal tissue: SLC28A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC28A3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
| smpdb | SMP00609 | Mercaptopurine Metabolism Pathway |
| pharmgkb | PA165859361 | Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics |
| pharmgkb | PA2036 | Gemcitabine Pathway, Pharmacodynamics |
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC28A3
CLASSFICATION
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