SLC28A3
Summary: Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608269 Ensembl IDEnsembl:ENSG00000197506 HGNC IDHGNC:HGNC:16484 PHARMGKB IDPA426 Map Location9q21.32-q21.33 | |||||
GO terms in SLC28A3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | IEA | GO:0015855 | pyrimidine nucleobase transport |
| BP | IBA | GO:0015860 | purine nucleoside transmembrane transport |
| BP | IEA | GO:0015860 | purine nucleoside transmembrane transport |
Gene expression in normal tissue: SLC28A3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC28A3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
| smpdb | SMP00609 | Mercaptopurine Metabolism Pathway |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC28A3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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