SRSF3
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine and arginine rich splicing factor 3 | MIM:603364 | Ensembl:ENSG00000112081 | HGNC:HGNC:10785 | PA35701 | 6p21.31-p21.2 |
GO terms in SRSF3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0043274 | phospholipase binding |
| MF | IEA | GO:1990825 | sequence-specific mRNA binding |
| BP | IBA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0006405 | RNA export from nucleus |
| BP | IDA | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0031124 | mRNA 3'-end processing |
| BP | IBA | GO:0045292 | mRNA cis splicing, via spliceosome |
| BP | IDA | GO:0048024 | regulation of mRNA splicing, via spliceosome |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0016607 | nuclear speck |
Gene expression in normal tissue: SRSF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRSF3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109688 | Cleavage of Growing Transcript in the Termination Region |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72187 | mRNA 3'-end processing |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-73856 | RNA Polymerase II Transcription Termination |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP411 | mRNA Processing |
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRSF3
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