CHST8


Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011].

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Gene Categories:

DRUGGABLE GENOME

GO terms in CHST8


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity
MF TAS GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity
CC TAS GO:0000139 Golgi membrane
CC NAS GO:0016021 integral component of membrane
BP IDA GO:0006790 sulfur compound metabolic process
BP NAS GO:0007417 central nervous system development
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Gene expression in normal tissue: CHST8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHST8


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Database
Pathway ID
Pathway Des.
wikipathways WP702 Metapathway biotransformation Phase I and II
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-446203 Asparagine N-linked glycosylation
reactome R-HSA-597592 Post-translational protein modification
reactome R-HSA-948021 Transport to the Golgi and subsequent modification
reactome R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHST8

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Cancer
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