CHST8


Summary: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
carbohydrate sulfotransferase 8MIM:610190Ensembl:ENSG00000124302HGNC:HGNC:15993PA2650819q13.11

Gene Categories:

DRUGGABLE GENOME

GO terms in CHST8


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity
MFTASGO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity
CCTASGO:0000139Golgi membrane
CCNASGO:0016021integral component of membrane
BPIDAGO:0006790sulfur compound metabolic process
BPNASGO:0007417central nervous system development
BPIEAGO:0016051carbohydrate biosynthetic process
BPIDAGO:0030166proteoglycan biosynthetic process
BPIEPGO:0042446hormone biosynthetic process

Gene expression in normal tissue: CHST8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CHST8


DatabasePathway IDPathway Des.
wikipathwaysWP702Metapathway biotransformation Phase I and II
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
reactomeR-HSA-975576N-glycan antennae elongation in the medial/trans-Golgi
reactomeR-HSA-975578Reactions specific to the complex N-glycan synthesis pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHST8

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