HHIP


Summary: This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
hedgehog interacting proteinMIM:606178Ensembl:ENSG00000164161HGNC:HGNC:14866PA292764q31.21

GO terms in HHIP


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003824catalytic activity
MFIPIGO:0005515protein binding
MFIDAGO:0008270zinc ion binding
MFIBAGO:0097108hedgehog family protein binding
MFIPIGO:0097108hedgehog family protein binding
BPIEAGO:0007224smoothened signaling pathway
BPIEAGO:0007405neuroblast proliferation
BPIEAGO:0009953dorsal/ventral pattern formation
BPIDAGO:0009968negative regulation of signal transduction
BPIEAGO:0040036regulation of fibroblast growth factor receptor signaling pathway
BPIEAGO:0043066negative regulation of apoptotic process
BPIBAGO:0045879negative regulation of smoothened signaling pathway
BPISSGO:0045879negative regulation of smoothened signaling pathway
BPISSGO:0048705skeletal system morphogenesis
BPIEAGO:0060441epithelial tube branching involved in lung morphogenesis
CCIEAGO:0005576extracellular region
CCIEAGO:0005634nucleus
CCIEAGO:0005737cytoplasm
CCISSGO:0005887integral component of plasma membrane
CCIEAGO:0009986cell surface
CCTASGO:0060170ciliary membrane

Gene expression in normal tissue: HHIP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HHIP


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5632681Ligand-receptor interactions
reactomeR-HSA-5632684Hedgehog 'on' state
netpathPathway_HedgehogHedgehog
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
wikipathwaysWP3313Hedgehog ,on, state
wikipathwaysWP4249Hedgehog Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HHIP

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