SH3GL2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SH3 domain containing GRB2 like 2, endophilin A1 | MIM:604465 | Ensembl:ENSG00000107295 | HGNC:HGNC:10831 | PA35737 | 9p22.2 |
GO terms in SH3GL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002090 | regulation of receptor internalization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | IEA | GO:0016191 | synaptic vesicle uncoating |
| BP | TAS | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0060988 | lipid tube assembly |
| BP | TAS | GO:0061024 | membrane organization |
| BP | ISS | GO:0097484 | dendrite extension |
| BP | IEA | GO:0097749 | membrane tubulation |
| BP | IEA | GO:0097753 | membrane bending |
| BP | IEA | GO:0099050 | vesicle scission |
| BP | IEA | GO:1903527 | positive regulation of membrane tubulation |
| BP | ISS | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| BP | IEA | GO:2000369 | regulation of clathrin-dependent endocytosis |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | ISS | GO:0005769 | early endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0097441 | basal dendrite |
| CC | IEA | GO:0098793 | presynapse |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: SH3GL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SH3GL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | rhoa_pathway | RhoA signaling pathway |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-177504 | Retrograde neurotrophin signalling |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-2132295 | MHC class II antigen presentation |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-432720 | Lysosome Vesicle Biogenesis |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SH3GL2
CLASSFICATION
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