STIL


Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
STIL, centriolar assembly proteinMIM:181590Ensembl:ENSG00000123473HGNC:HGNC:10879PA357801p33

Gene Categories:

TUMOR SUPPRESSOR

GO terms in STIL


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIBAGO:0005813centrosome
CCIDAGO:0005813centrosome
CCIBAGO:0005814centriole
CCIDAGO:0005814centriole
CCIEAGO:0005829cytosol
BPISSGO:0000578embryonic axis specification
BPISSGO:0001701in utero embryonic development
BPISSGO:0001843neural tube closure
BPISSGO:0001947heart looping
BPIBAGO:0007052mitotic spindle organization
BPIMPGO:0007052mitotic spindle organization
BPIBAGO:0007224smoothened signaling pathway
BPISSGO:0007224smoothened signaling pathway
BPISSGO:0007368determination of left/right symmetry
BPTASGO:0008283cell proliferation
BPISSGO:0021915neural tube development
BPISSGO:0030900forebrain development
BPISSGO:0030903notochord development
BPISSGO:0033504floor plate development
BPISSGO:0035264multicellular organism growth
BPISSGO:0043066negative regulation of apoptotic process
BPIMPGO:0046599regulation of centriole replication
BPIBAGO:0051298centrosome duplication
BPIDAGO:0051298centrosome duplication
BPIMPGO:0051298centrosome duplication
BPIBAGO:0071539protein localization to centrosome
BPIMPGO:0071539protein localization to centrosome
MFIPIGO:0005515protein binding

Gene expression in normal tissue: STIL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STIL


DatabasePathway IDPathway Des.
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD187BRD98761
iGMDRD138PX 122
iGMDRD513BML-2591
iGMDRD255SB2250026
iGMDRD64Parbendazole2
iGMDRD268Cerulenin2
iGMDRD356PNU-746542
iGMDRD188Piperlongumine2
iGMDRD577BIX012941
iGMDRD888Compound 444
iGMDRD546BMS-7548072
iGMDRD144NSC953972
iGMDRD433Lexibulin2
iGMDRD420Leucascandrolide A1
iGMDRD201SKI II3
iGMDRD193Fqi11
iGMDRD289Parthenolide5
iGMDRD105Triptolide1
iGMDRD246NPC262
iGMDRD300Tozasertib3
iGMDRD82Quiflapon3
iGMDRD286Nsc 6328391
iGMDRD871BRD63683
iGMDRD329Merck606
iGMDRD662JQ-12
iGMDRD424Tamatinib3
iGMDRD116CD4376
iGMDRD405PIK-753
iGMDRD307Manumycin A1
iGMDRD123Isoevodiamine2
iGMDRD945ML2142
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD85Ursolic acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STIL

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