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STIL

Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
STIL, centriolar assembly protein	MIM:181590	Ensembl:ENSG00000123473	HGNC:HGNC:10879	PA35780	1p33

Gene Categories:

TUMOR SUPPRESSOR

GO terms in STIL

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005737	cytoplasm
CC	IBA	GO:0005813	centrosome
CC	IDA	GO:0005813	centrosome
CC	IBA	GO:0005814	centriole
CC	IDA	GO:0005814	centriole
CC	IEA	GO:0005829	cytosol
BP	ISS	GO:0000578	embryonic axis specification
BP	ISS	GO:0001701	in utero embryonic development
BP	ISS	GO:0001843	neural tube closure
BP	ISS	GO:0001947	heart looping
BP	IBA	GO:0007052	mitotic spindle organization
BP	IMP	GO:0007052	mitotic spindle organization
BP	IBA	GO:0007224	smoothened signaling pathway
BP	ISS	GO:0007224	smoothened signaling pathway
BP	ISS	GO:0007368	determination of left/right symmetry
BP	TAS	GO:0008283	cell proliferation
BP	ISS	GO:0021915	neural tube development
BP	ISS	GO:0030900	forebrain development
BP	ISS	GO:0030903	notochord development
BP	ISS	GO:0033504	floor plate development
BP	ISS	GO:0035264	multicellular organism growth
BP	ISS	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0046599	regulation of centriole replication
BP	IBA	GO:0051298	centrosome duplication
BP	IDA	GO:0051298	centrosome duplication
BP	IMP	GO:0051298	centrosome duplication
BP	IBA	GO:0071539	protein localization to centrosome
BP	IMP	GO:0071539	protein localization to centrosome
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: STIL

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STIL

Database	Pathway ID	Pathway Des.
pid	hedgehog_2pathway	Signaling events mediated by the Hedgehog family

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD187	BRD9876	1
iGMDRD138	PX 12	2
iGMDRD513	BML-259	1
iGMDRD255	SB225002	6
iGMDRD64	Parbendazole	2
iGMDRD268	Cerulenin	2
iGMDRD356	PNU-74654	2
iGMDRD188	Piperlongumine	2
iGMDRD577	BIX01294	1
iGMDRD888	Compound 44	4
iGMDRD546	BMS-754807	2
iGMDRD144	NSC95397	2
iGMDRD433	Lexibulin	2
iGMDRD420	Leucascandrolide A	1
iGMDRD201	SKI II	3
iGMDRD193	Fqi1	1
iGMDRD289	Parthenolide	5
iGMDRD105	Triptolide	1
iGMDRD246	NPC26	2
iGMDRD300	Tozasertib	3
iGMDRD82	Quiflapon	3
iGMDRD286	Nsc 632839	1
iGMDRD871	BRD6368	3
iGMDRD329	Merck60	6
iGMDRD662	JQ-1	2
iGMDRD424	Tamatinib	3
iGMDRD116	CD437	6
iGMDRD405	PIK-75	3
iGMDRD307	Manumycin A	1
iGMDRD123	Isoevodiamine	2
iGMDRD945	ML214	2
iGMDRD132	(-)-gallocatechin-3-O-gallate	4
iGMDRD85	Ursolic acid	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STIL

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.