SLC1A5
Summary: The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 1 member 5 | MIM:109190 | Ensembl:ENSG00000105281 | HGNC:HGNC:10943 | PA35830 | 19q13.32 |
Gene Categories:
TRANSPORTERGO terms in SLC1A5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015171 | amino acid transmembrane transporter activity |
| MF | TAS | GO:0015175 | neutral amino acid transmembrane transporter activity |
| MF | TAS | GO:0015186 | L-glutamine transmembrane transporter activity |
| MF | IEA | GO:0015194 | L-serine transmembrane transporter activity |
| MF | IEA | GO:0015293 | symporter activity |
| MF | TAS | GO:0038023 | signaling receptor activity |
| BP | TAS | GO:0006865 | amino acid transport |
| BP | TAS | GO:0006868 | glutamine transport |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0010585 | glutamine secretion |
| BP | TAS | GO:0015804 | neutral amino acid transport |
| BP | IEA | GO:0015825 | L-serine transport |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEA | GO:1903803 | L-glutamine import across plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0042470 | melanosome |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: SLC1A5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC1A5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| smpdb | SMP00001 | Citrullinemia Type I |
| smpdb | SMP00002 | Carbamoyl Phosphate Synthetase Deficiency |
| smpdb | SMP00003 | Argininosuccinic Aciduria |
| smpdb | SMP00059 | Urea Cycle |
| smpdb | SMP00205 | Ornithine Transcarbamylase Deficiency (OTC Deficiency) |
| smpdb | SMP00357 | Argininemia |
| smpdb | SMP00654 | Warburg Effect |
| smpdb | SMP02298 | Glutaminolysis and Cancer |
| wikipathways | WP3945 | TYROBP Causal Network |
| wikipathways | WP3953 | mRNA, protein, and metabolite inducation pathway by cyclosporin A |
| reactome | R-HSA-352230 | Amino acid transport across the plasma membrane |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC1A5
CLASSFICATION
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