SLC3A1
Summary: This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:104614 Ensembl IDEnsembl:ENSG00000138079 HGNC IDHGNC:HGNC:11025 PHARMGKB IDPA35893 Map Location2p21 | |||||
GO terms in SLC3A1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0005975 | carbohydrate metabolic process |
| BP | TAS | GO:0006520 | cellular amino acid metabolic process |
| BP | IBA | GO:0006865 | amino acid transport |
| BP | TAS | GO:0006865 | amino acid transport |
| BP | IBA | GO:0009313 | oligosaccharide catabolic process |
| BP | TAS | GO:0015802 | basic amino acid transport |
Gene expression in normal tissue: SLC3A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC3A1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-352230 | Amino acid transport across the plasma membrane |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425393 | Transport of inorganic cations/anions and amino acids/oligopeptides |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-5619102 | SLC transporter disorders |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC3A1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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