SLC5A2
Summary: This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:182381 Ensembl IDEnsembl:ENSG00000140675 HGNC IDHGNC:HGNC:11037 PHARMGKB IDPA35902 Map Location16p11.2 | |||||
GO terms in SLC5A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0005975 | carbohydrate metabolic process |
| BP | IBA | GO:0006814 | sodium ion transport |
| BP | IEA | GO:0006814 | sodium ion transport |
| BP | TAS | GO:0008645 | hexose transmembrane transport |
| BP | IEA | GO:1904659 | glucose transmembrane transport |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: SLC5A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC5A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-189200 | Cellular hexose transport |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC5A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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