SLCO1A2
Summary: This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602883 Ensembl IDEnsembl:ENSG00000084453 HGNC IDHGNC:HGNC:10956 PHARMGKB IDPA328 Map Location12p12.1 | |||||
GO terms in SLCO1A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | TAS | GO:0015711 | organic anion transport |
| BP | IBA | GO:0015721 | bile acid and bile salt transport |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
Gene expression in normal tissue: SLCO1A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLCO1A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| pharmgkb | PA145011108 | Statin Pathway - Generalized, Pharmacokinetics |
| pharmgkb | PA165816270 | Methotrexate Pathway (Brain Cell), Pharmacokinetics |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLCO1A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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