SLIT3
Summary: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603745 Ensembl IDEnsembl:ENSG00000184347 HGNC IDHGNC:HGNC:11087 PHARMGKB IDPA35940 Map Location5q34-q35.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in SLIT3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005615 | extracellular space |
| CC | NAS | GO:0005739 | mitochondrion |
| BP | ISS | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003181 | atrioventricular valve morphogenesis |
| BP | IDA | GO:0007411 | axon guidance |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
Gene expression in normal tissue: SLIT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLIT3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| wikipathways | WP2431 | Spinal Cord Injury |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLIT3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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