SLIT3
Summary: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| slit guidance ligand 3 | MIM:603745 | Ensembl:ENSG00000184347 | HGNC:HGNC:11087 | PA35940 | 5q34-q35.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in SLIT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005615 | extracellular space |
| CC | NAS | GO:0005739 | mitochondrion |
| BP | ISS | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003181 | atrioventricular valve morphogenesis |
| BP | IDA | GO:0007411 | axon guidance |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IDA | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration |
| BP | IMP | GO:0030308 | negative regulation of cell growth |
| BP | IEP | GO:0032870 | cellular response to hormone stimulus |
| BP | IMP | GO:0035385 | Roundabout signaling pathway |
| BP | IDA | GO:0048846 | axon extension involved in axon guidance |
| BP | IDA | GO:0050919 | negative chemotaxis |
| BP | IEP | GO:0051414 | response to cortisol |
| BP | ISS | GO:0060412 | ventricular septum morphogenesis |
| BP | IEP | GO:0061364 | apoptotic process involved in luteolysis |
| BP | IMP | GO:0070100 | negative regulation of chemokine-mediated signaling pathway |
| MF | NAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0048495 | Roundabout binding |
Gene expression in normal tissue: SLIT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLIT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| wikipathways | WP2431 | Spinal Cord Injury |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLIT3
CLASSFICATION
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