SNRPB


Summary: The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
small nuclear ribonucleoprotein polypeptides B and B1MIM:182282Ensembl:ENSG00000125835HGNC:HGNC:11153PA3599520p13

GO terms in SNRPB


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIPIGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0030620U2 snRNA binding
MFIPIGO:0070034telomerase RNA binding
MFIEAGO:0071208histone pre-mRNA DCP binding
BPIDAGO:0000387spliceosomal snRNP assembly
BPTASGO:0000387spliceosomal snRNP assembly
BPIBAGO:0000398mRNA splicing, via spliceosome
BPICGO:0000398mRNA splicing, via spliceosome
BPIDAGO:0000398mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006369termination of RNA polymerase II transcription
BPIDAGO:0006479protein methylation
BPTASGO:0008334histone mRNA metabolic process
BPTASGO:0008380RNA splicing
BPTASGO:0051170import into nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCTASGO:0005681spliceosomal complex
CCIBAGO:0005682U5 snRNP
CCIDAGO:0005683U7 snRNP
CCIBAGO:0005685U1 snRNP
CCIDAGO:0005685U1 snRNP
CCIBAGO:0005686U2 snRNP
CCIBAGO:0005687U4 snRNP
CCIDAGO:0005687U4 snRNP
CCIDAGO:0005689U12-type spliceosomal complex
CCIDAGO:0005697telomerase holoenzyme complex
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0030532small nuclear ribonucleoprotein complex
CCIDAGO:0034709methylosome
CCIDAGO:0034719SMN-Sm protein complex
CCIBAGO:0046540U4/U6 x U5 tri-snRNP complex
CCIBAGO:0071004U2-type prespliceosome
CCIDAGO:0071005U2-type precatalytic spliceosome
CCIDAGO:0071007U2-type catalytic step 2 spliceosome
CCIBAGO:0071013catalytic step 2 spliceosome
CCIDAGO:0071013catalytic step 2 spliceosome
CCIEAGO:0071204histone pre-mRNA 3'end processing complex

Gene expression in normal tissue: SNRPB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SNRPB


DatabasePathway IDPathway Des.
kegghsa03040Spliceosome - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
wikipathwaysWP411mRNA Processing
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-111367SLBP independent Processing of Histone Pre-mRNAs
reactomeR-HSA-191859snRNP Assembly
reactomeR-HSA-194441Metabolism of non-coding RNA
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72165mRNA Splicing - Minor Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75067Processing of Capped Intronless Pre-mRNA
reactomeR-HSA-77588SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SNRPB

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