SNRPB
Summary: The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:182282 Ensembl IDEnsembl:ENSG00000125835 HGNC IDHGNC:HGNC:11153 PHARMGKB IDPA35995 Map Location20p13 | |||||
GO terms in SNRPB
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030620 | U2 snRNA binding |
| MF | IPI | GO:0070034 | telomerase RNA binding |
| MF | IEA | GO:0071208 | histone pre-mRNA DCP binding |
Gene expression in normal tissue: SNRPB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SNRPB
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| wikipathways | WP411 | mRNA Processing |
| reactome | R-HSA-109688 | Cleavage of Growing Transcript in the Termination Region |
| reactome | R-HSA-111367 | SLBP independent Processing of Histone Pre-mRNAs |
| reactome | R-HSA-191859 | snRNP Assembly |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SNRPB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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