SOX1

Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameSRY-box 1
OMIM IDMIM:602148
Ensembl IDEnsembl:ENSG00000182968
HGNC IDHGNC:HGNC:11189
PHARMGKB IDPA36026
Map Location13q34

GO terms in SOX1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001764 neuron migration
BP IEA GO:0002089 lens morphogenesis in camera-type eye
BP NAS GO:0006325 chromatin organization
BP IBA GO:0006355 regulation of transcription, DNA-templated
BP NAS GO:0006355 regulation of transcription, DNA-templated
BP IEA GO:0006366 transcription by RNA polymerase II
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Gene expression in normal tissue: SOX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOX1


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Database
Pathway ID
Pathway Des.
wikipathways WP2406 Cardiac Progenitor Differentiation
wikipathways WP363 Wnt Signaling Pathway
netpath Pathway_Wnt Wnt
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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