SOX1
Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SRY-box 1 | MIM:602148 | Ensembl:ENSG00000182968 | HGNC:HGNC:11189 | PA36026 | 13q34 |
GO terms in SOX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0002089 | lens morphogenesis in camera-type eye |
| BP | NAS | GO:0006325 | chromatin organization |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IBA | GO:0007417 | central nervous system development |
| BP | IBA | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0021521 | ventral spinal cord interneuron specification |
| BP | IEA | GO:0021884 | forebrain neuron development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | IBA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IBA | GO:0044798 | nuclear transcription factor complex |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | NAS | GO:0003677 | DNA binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SOX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP363 | Wnt Signaling Pathway |
| netpath | Pathway_Wnt | Wnt |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOX1
CLASSFICATION
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