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SP4

Summary: The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameSp4 transcription factor OMIM IDMIM:600540 Ensembl IDEnsembl:ENSG00000105866 HGNC IDHGNC:HGNC:11209 PHARMGKB IDPA36046 Map Location7p15.3

GO terms in SP4

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IBA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IDA	GO:0006357	regulation of transcription by RNA polymerase II
BP	IEA	GO:1903508	positive regulation of nucleic acid-templated transcription
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm

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Gene expression in normal tissue: SP4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SP4

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SP4

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.