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SPIB

Summary: The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameSpi-B transcription factor OMIM IDMIM:606802 Ensembl IDEnsembl:ENSG00000269404 HGNC IDHGNC:HGNC:11242 PHARMGKB IDPA36072 Map Location19q13.33

GO terms in SPIB

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IMP	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IMP	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
BP	IBA	GO:0006357	regulation of transcription by RNA polymerase II
BP	TAS	GO:0006357	regulation of transcription by RNA polymerase II

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Gene expression in normal tissue: SPIB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPIB

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPIB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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