BPI


Summary: This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

DRUGGABLE GENOME

GO terms in BPI


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0001530 lipopolysaccharide binding
BP TAS GO:0019730 antimicrobial humoral response
BP IDA GO:0032715 negative regulation of interleukin-6 production
BP IDA GO:0032717 negative regulation of interleukin-8 production
BP IDA GO:0032720 negative regulation of tumor necrosis factor production
BP IDA GO:0043031 negative regulation of macrophage activation
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Gene expression in normal tissue: BPI

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in BPI


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Database
Pathway ID
Pathway Des.
reactome R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-168898 Toll-Like Receptors Cascades
reactome R-HSA-6798695 Neutrophil degranulation
reactome R-HSA-6803157 Antimicrobial peptides
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BPI

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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