ZFP36L1
Summary: This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601064 Ensembl IDEnsembl:ENSG00000185650 HGNC IDHGNC:HGNC:1107 PHARMGKB IDPA35027 Map Location14q24.1 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in ZFP36L1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0003342 | proepicardium development |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006397 | mRNA processing |
Gene expression in normal tissue: ZFP36L1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZFP36L1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| reactome | R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD1019 | TL-2-105 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZFP36L1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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