ZFP36L1
Summary: This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ZFP36 ring finger protein like 1 | MIM:601064 | Ensembl:ENSG00000185650 | HGNC:HGNC:1107 | PA35027 | 14q24.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in ZFP36L1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0003342 | proepicardium development |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IDA | GO:0009611 | response to wounding |
| BP | IDA | GO:0010468 | regulation of gene expression |
| BP | IMP | GO:0010837 | regulation of keratinocyte proliferation |
| BP | IDA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0021915 | neural tube development |
| BP | ISS | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
| BP | IDA | GO:0031440 | regulation of mRNA 3'-end processing |
| BP | IDA | GO:0032869 | cellular response to insulin stimulus |
| BP | ISS | GO:0033077 | T cell differentiation in thymus |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | ISS | GO:0038066 | p38MAPK cascade |
| BP | IDA | GO:0043488 | regulation of mRNA stability |
| BP | IMP | GO:0043488 | regulation of mRNA stability |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | ISS | GO:0043491 | protein kinase B signaling |
| BP | ISS | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| BP | ISS | GO:0045577 | regulation of B cell differentiation |
| BP | ISS | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IMP | GO:0045616 | regulation of keratinocyte differentiation |
| BP | IDA | GO:0045647 | negative regulation of erythrocyte differentiation |
| BP | IDA | GO:0045657 | positive regulation of monocyte differentiation |
| BP | ISS | GO:0045661 | regulation of myoblast differentiation |
| BP | ISS | GO:0048382 | mesendoderm development |
| BP | IMP | GO:0051028 | mRNA transport |
| BP | IEA | GO:0060710 | chorio-allantoic fusion |
| BP | IEA | GO:0060712 | spongiotrophoblast layer development |
| BP | IBA | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IDA | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IMP | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| BP | IDA | GO:0070371 | ERK1 and ERK2 cascade |
| BP | IDA | GO:0071320 | cellular response to cAMP |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IDA | GO:0071375 | cellular response to peptide hormone stimulus |
| BP | IDA | GO:0071385 | cellular response to glucocorticoid stimulus |
| BP | IMP | GO:0071456 | cellular response to hypoxia |
| BP | ISS | GO:0071472 | cellular response to salt stress |
| BP | IDA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | ISS | GO:0072091 | regulation of stem cell proliferation |
| BP | ISS | GO:0097403 | cellular response to raffinose |
| BP | ISS | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| BP | ISS | GO:1901991 | negative regulation of mitotic cell cycle phase transition |
| BP | IMP | GO:1902172 | regulation of keratinocyte apoptotic process |
| BP | IMP | GO:1904582 | positive regulation of intracellular mRNA localization |
| CC | IDA | GO:0000932 | P-body |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0071889 | 14-3-3 protein binding |
Gene expression in normal tissue: ZFP36L1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZFP36L1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| reactome | R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ZFP36L1
CLASSFICATION
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