Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013].

ATP binding cassette subfamily C member 8MIM:600509Ensembl:ENSG00000006071HGNC:HGNC:59PA2439511p15.1

GO terms in ABCC8

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005267potassium channel activity
MFIMPGO:0005267potassium channel activity
MFIEAGO:0005524ATP binding
MFIEAGO:0008281sulfonylurea receptor activity
MFTASGO:0015272ATP-activated inward rectifier potassium channel activity
MFIBAGO:0042626ATPase activity, coupled to transmembrane movement of substances
MFIPIGO:0044325ion channel binding
BPIBAGO:0006813potassium ion transport
BPTASGO:0006813potassium ion transport
BPIEAGO:0007165signal transduction
BPIBAGO:0042493response to drug
BPTASGO:0050796regulation of insulin secretion
BPIBAGO:0055085transmembrane transport
BPIEAGO:0071805potassium ion transmembrane transport
CCTASGO:0005886plasma membrane
CCIBAGO:0008282inward rectifying potassium channel
CCIDAGO:0008282inward rectifying potassium channel

Gene expression in normal tissue: ABCC8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABCC8

DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296025ATP sensitive Potassium channels
reactomeR-HSA-1296065Inwardly rectifying K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-5619084ABC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5683177Defective ABCC8 can cause hypoglycemias and hyperglycemias
pidhnf3bpathwayFOXA2 and FOXA3 transcription factor networks
kegghsa02010ABC transporters - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
smpdbSMP00296Acebutolol Action Pathway
smpdbSMP00297Alprenolol Action Pathway
smpdbSMP00298Atenolol Action Pathway
smpdbSMP00299Betaxolol Action Pathway
smpdbSMP00300Bisoprolol Action Pathway
smpdbSMP00301Esmolol Action Pathway
smpdbSMP00302Metoprolol Action Pathway
smpdbSMP00303Nadolol Action Pathway
smpdbSMP00304Oxprenolol Action Pathway
smpdbSMP00305Penbutolol Action Pathway
smpdbSMP00306Pindolol Action Pathway
smpdbSMP00307Propranolol Action Pathway
smpdbSMP00323Quinidine Action Pathway
smpdbSMP00324Procainamide (Antiarrhythmic) Action Pathway
smpdbSMP00325Disopyramide Action Pathway
smpdbSMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00328Lidocaine (Antiarrhythmic) Action Pathway
smpdbSMP00329Mexiletine Action Pathway
smpdbSMP00330Tocainide Action Pathway
smpdbSMP00331Flecainide Action Pathway
smpdbSMP00332Ibutilide Action Pathway
smpdbSMP00359Diltiazem Action Pathway
smpdbSMP00366Nebivolol Action Pathway
smpdbSMP00367Carvedilol Action Pathway
smpdbSMP00368Labetalol Action Pathway
smpdbSMP00375Verapamil Action Pathway
smpdbSMP00376Amlodipine Action Pathway
smpdbSMP00377Felodipine Action Pathway
smpdbSMP00378Isradipine Action Pathway
smpdbSMP00379Nifedipine Action Pathway
smpdbSMP00380Nimodipine Action Pathway
smpdbSMP00381Nisoldipine Action Pathway
smpdbSMP00382Nitrendipine Action Pathway
smpdbSMP00453Nateglinide Action Pathway
smpdbSMP00454Repaglinide Action Pathway
smpdbSMP00460Glibenclamide Action Pathway
smpdbSMP00461Gliclazide Action Pathway
smpdbSMP00588Muscle/Heart Contraction
smpdbSMP00643Pancreas Function
smpdbSMP00657Bopindolol Action Pathway
smpdbSMP00658Carteolol Action Pathway
smpdbSMP00659Timolol Action Pathway
smpdbSMP00660Sotalol Action Pathway
smpdbSMP00661Epinephrine Action Pathway
smpdbSMP00662Dobutamine Action Pathway
smpdbSMP00663Isoprenaline Action Pathway
smpdbSMP00664Arbutamine Action Pathway
smpdbSMP00665Amiodarone Action Pathway
smpdbSMP00666Levobunolol Action Pathway
smpdbSMP00667Metipranolol Action Pathway
smpdbSMP00668Bevantolol Action Pathway
smpdbSMP00669Practolol Action Pathway
smpdbSMP00670Bupranolol Action Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCC8