SURF4
Summary: This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
surfeit 4 | MIM:185660 | Ensembl:ENSG00000148248 | HGNC:HGNC:11476 | PA36261 | 9q34.2 |
GO terms in SURF4
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
BP | TAS | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
BP | IMP | GO:0007030 | Golgi organization |
BP | IMP | GO:0010638 | positive regulation of organelle organization |
BP | IMP | GO:0032527 | protein exit from endoplasmic reticulum |
BP | IMP | GO:0034498 | early endosome to Golgi transport |
BP | TAS | GO:0043312 | neutrophil degranulation |
CC | TAS | GO:0000139 | Golgi membrane |
CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
CC | IDA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
CC | TAS | GO:0005886 | plasma membrane |
CC | IEA | GO:0016021 | integral component of membrane |
CC | TAS | GO:0030133 | transport vesicle |
CC | IEA | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
CC | TAS | GO:0035577 | azurophil granule membrane |
Gene expression in normal tissue: SURF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SURF4
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-168249 | Innate Immune System |
reactome | R-HSA-168256 | Immune System |
reactome | R-HSA-199991 | Membrane Trafficking |
reactome | R-HSA-5653656 | Vesicle-mediated transport |
reactome | R-HSA-6798695 | Neutrophil degranulation |
reactome | R-HSA-6811434 | COPI-dependent Golgi-to-ER retrograde traffic |
reactome | R-HSA-6811442 | Intra-Golgi and retrograde Golgi-to-ER traffic |
reactome | R-HSA-8856688 | Golgi-to-ER retrograde transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SURF4