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SUV39H1

Summary: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
suppressor of variegation 3-9 homolog 1	MIM:300254	Ensembl:ENSG00000101945	HGNC:HGNC:11479	PA36264	Xp11.23

Gene Categories:

HISTONE MODIFICATION DRUGGABLE GENOME METHYL TRANSFERASE

GO terms in SUV39H1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IDA	GO:0000183	chromatin silencing at rDNA
BP	TAS	GO:0000183	chromatin silencing at rDNA
BP	TAS	GO:0006325	chromatin organization
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006364	rRNA processing
BP	IDA	GO:0006974	cellular response to DNA damage stimulus
BP	IEA	GO:0007049	cell cycle
BP	IEA	GO:0016032	viral process
BP	IEA	GO:0030154	cell differentiation
BP	ISS	GO:0036123	histone H3-K9 dimethylation
BP	ISS	GO:0036124	histone H3-K9 trimethylation
BP	ISS	GO:0042754	negative regulation of circadian rhythm
BP	ISS	GO:0045892	negative regulation of transcription, DNA-templated
BP	IEA	GO:0048511	rhythmic process
BP	IDA	GO:0071456	cellular response to hypoxia
CC	IEA	GO:0000775	chromosome, centromeric region
CC	IDA	GO:0000792	heterochromatin
CC	TAS	GO:0000794	condensed nuclear chromosome
CC	IDA	GO:0005634	nucleus
CC	IEA	GO:0005652	nuclear lamina
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005677	chromatin silencing complex
CC	IDA	GO:0033553	rDNA heterochromatin
MF	ISS	GO:0000976	transcription regulatory region sequence-specific DNA binding
MF	TAS	GO:0003682	chromatin binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008270	zinc ion binding
MF	IDA	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
MF	IDA	GO:0018024	histone-lysine N-methyltransferase activity
MF	TAS	GO:0018024	histone-lysine N-methyltransferase activity
MF	IDA	GO:0042054	histone methyltransferase activity
MF	EXP	GO:0046974	histone methyltransferase activity (H3-K9 specific)
MF	IDA	GO:0046974	histone methyltransferase activity (H3-K9 specific)
MF	IPI	GO:0047485	protein N-terminus binding

Gene expression in normal tissue: SUV39H1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SUV39H1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-212165	Epigenetic regulation of gene expression
reactome	R-HSA-3214841	PKMTs methylate histone lysines
reactome	R-HSA-3247509	Chromatin modifying enzymes
reactome	R-HSA-427359	SIRT1 negatively regulates rRNA expression
reactome	R-HSA-4839726	Chromatin organization
reactome	R-HSA-5250941	Negative epigenetic regulation of rRNA expression
reactome	R-HSA-74160	Gene expression (Transcription)
kegg	hsa00310	Lysine degradation - Homo sapiens (human)
pid	rb_1pathway	Regulation of retinoblastoma protein
wikipathways	WP2369	Histone Modifications
wikipathways	WP2446	Retinoblastoma (RB) in Cancer
wikipathways	WP3670	Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD68	Paclitaxel	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUV39H1

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DATATYPES

CLASSFICATION

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