SUV39H1
Summary: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300254 Ensembl IDEnsembl:ENSG00000101945 HGNC IDHGNC:HGNC:11479 PHARMGKB IDPA36264 Map LocationXp11.23 | |||||
GO terms in SUV39H1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000183 | chromatin silencing at rDNA |
| BP | TAS | GO:0000183 | chromatin silencing at rDNA |
| BP | TAS | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006364 | rRNA processing |
Gene expression in normal tissue: SUV39H1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SUV39H1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-427359 | SIRT1 negatively regulates rRNA expression |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD68 | Paclitaxel | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SUV39H1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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