SUV39H1


Summary: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

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GO terms in SUV39H1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0000122 negative regulation of transcription by RNA polymerase II
BP IDA GO:0000183 chromatin silencing at rDNA
BP TAS GO:0000183 chromatin silencing at rDNA
BP TAS GO:0006325 chromatin organization
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006364 rRNA processing
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Gene expression in normal tissue: SUV39H1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Metabolic pathways1

Pathways in SUV39H1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-212165 Epigenetic regulation of gene expression
reactome R-HSA-3214841 PKMTs methylate histone lysines
reactome R-HSA-3247509 Chromatin modifying enzymes
reactome R-HSA-427359 SIRT1 negatively regulates rRNA expression
reactome R-HSA-4839726 Chromatin organization
reactome R-HSA-5250941 Negative epigenetic regulation of rRNA expression
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUV39H1

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Model
Level
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Cancer
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No matching records found

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