VAMP2
Summary: The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:185881 Ensembl IDEnsembl:ENSG00000220205 HGNC IDHGNC:HGNC:12643 PHARMGKB IDPA37267 Map Location17p13.1 |
GO terms in VAMP2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISS | GO:0000149 | SNARE binding |
MF | IPI | GO:0005515 | protein binding |
MF | ISS | GO:0005516 | calmodulin binding |
MF | ISS | GO:0005543 | phospholipid binding |
MF | ISS | GO:0017075 | syntaxin-1 binding |
MF | IBA | GO:0019905 | syntaxin binding |
Gene expression in normal tissue: VAMP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VAMP2
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | botulinumtoxinpathway | Effects of Botulinum toxin |
pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
kegg | hsa04130 | SNARE interactions in vesicular transport - Homo sapiens (human) |
kegg | hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
kegg | hsa04962 | Vasopressin-regulated water reabsorption - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in VAMP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |