VAMP2


Summary: The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in VAMP2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0000149 SNARE binding
MF IPI GO:0005515 protein binding
MF ISS GO:0005516 calmodulin binding
MF ISS GO:0005543 phospholipid binding
MF ISS GO:0017075 syntaxin-1 binding
MF IBA GO:0019905 syntaxin binding
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Gene expression in normal tissue: VAMP2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in VAMP2


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Database
Pathway ID
Pathway Des.
pid botulinumtoxinpathway Effects of Botulinum toxin
pid insulin_glucose_pathway Insulin-mediated glucose transport
kegg hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human)
kegg hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
kegg hsa04911 Insulin secretion - Homo sapiens (human)
kegg hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VAMP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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