SYN2
Summary: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namesynapsin II OMIM IDMIM:600755 Ensembl IDEnsembl:ENSG00000157152 HGNC IDHGNC:HGNC:11495 PHARMGKB IDPA36277 Map Location3p25.2 | |||||
GO terms in SYN2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0007269 | neurotransmitter secretion |
| BP | ISS | GO:0007269 | neurotransmitter secretion |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0030672 | synaptic vesicle membrane |
| CC | ISS | GO:0030672 | synaptic vesicle membrane |
Gene expression in normal tissue: SYN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SYN2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112310 | Neurotransmitter release cycle |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-181429 | Serotonin Neurotransmitter Release Cycle |
| reactome | R-HSA-212676 | Dopamine Neurotransmitter Release Cycle |
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SYN2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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