SYN2


Summary: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
synapsin IIMIM:600755Ensembl:ENSG00000157152HGNC:HGNC:11495PA362773p25.2

GO terms in SYN2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007268chemical synaptic transmission
BPIBAGO:0007269neurotransmitter secretion
BPISSGO:0007269neurotransmitter secretion
CCIEAGO:0030054cell junction
CCIBAGO:0030672synaptic vesicle membrane
CCISSGO:0030672synaptic vesicle membrane
CCISSGO:0045202synapse
MFTASGO:0005524ATP binding

Gene expression in normal tissue: SYN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SYN2


DatabasePathway IDPathway Des.
reactomeR-HSA-112310Neurotransmitter release cycle
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-181429Serotonin Neurotransmitter Release Cycle
reactomeR-HSA-212676Dopamine Neurotransmitter Release Cycle
wikipathwaysWP2267Synaptic Vesicle Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SYN2

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