TACR1
Summary: This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tachykinin receptor 1 | MIM:162323 | Ensembl:ENSG00000115353 | HGNC:HGNC:11526 | PA36302 | 2p12 |
GO terms in TACR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004995 | tachykinin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016496 | substance P receptor activity |
| MF | IMP | GO:0016496 | substance P receptor activity |
| BP | IEA | GO:0002118 | aggressive behavior |
| BP | IEA | GO:0002526 | acute inflammatory response |
| BP | IEA | GO:0002687 | positive regulation of leukocyte migration |
| BP | IEA | GO:0003051 | angiotensin-mediated drinking behavior |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IDA | GO:0007217 | tachykinin receptor signaling pathway |
| BP | IMP | GO:0007217 | tachykinin receptor signaling pathway |
| BP | IEA | GO:0007616 | long-term memory |
| BP | IEA | GO:0008306 | associative learning |
| BP | IEA | GO:0009408 | response to heat |
| BP | TAS | GO:0009582 | detection of abiotic stimulus |
| BP | IEA | GO:0010193 | response to ozone |
| BP | IEA | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IEA | GO:0010996 | response to auditory stimulus |
| BP | IEA | GO:0014910 | regulation of smooth muscle cell migration |
| BP | IEA | GO:0019233 | sensory perception of pain |
| BP | IEA | GO:0032224 | positive regulation of synaptic transmission, cholinergic |
| BP | IEA | GO:0032230 | positive regulation of synaptic transmission, GABAergic |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | IEA | GO:0035106 | operant conditioning |
| BP | IEA | GO:0035815 | positive regulation of renal sodium excretion |
| BP | IEA | GO:0042713 | sperm ejaculation |
| BP | IEA | GO:0042755 | eating behavior |
| BP | IEA | GO:0043117 | positive regulation of vascular permeability |
| BP | IEA | GO:0043278 | response to morphine |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0045760 | positive regulation of action potential |
| BP | IEA | GO:0045777 | positive regulation of blood pressure |
| BP | IEA | GO:0045778 | positive regulation of ossification |
| BP | IEA | GO:0045907 | positive regulation of vasoconstriction |
| BP | IEA | GO:0046878 | positive regulation of saliva secretion |
| BP | IEA | GO:0046887 | positive regulation of hormone secretion |
| BP | IEA | GO:0048266 | behavioral response to pain |
| BP | IEA | GO:0048660 | regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0050671 | positive regulation of lymphocyte proliferation |
| BP | IEA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IEA | GO:0051602 | response to electrical stimulus |
| BP | IEA | GO:0060083 | smooth muscle contraction involved in micturition |
| BP | IEA | GO:0070474 | positive regulation of uterine smooth muscle contraction |
| BP | IMP | GO:1902093 | positive regulation of flagellated sperm motility |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0036126 | sperm flagellum |
| CC | IEA | GO:0044297 | cell body |
| CC | IDA | GO:0061827 | sperm head |
| CC | IDA | GO:0097225 | sperm midpiece |
Gene expression in normal tissue: TACR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TACR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380095 | Tachykinin receptors bind tachykinins |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TACR1
CLASSFICATION
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