TAF11


Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TATA-box binding protein associated factor 11MIM:600772Ensembl:ENSG00000064995HGNC:HGNC:11544PA363196p21.31

GO terms in TAF11


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006355regulation of transcription, DNA-templated
BPICGO:0006366transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPICGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0042795snRNA transcription by RNA polymerase II
BPIDAGO:0043923positive regulation by host of viral transcription
BPIBAGO:0051123RNA polymerase II transcriptional preinitiation complex assembly
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005669transcription factor TFIID complex
CCIDAGO:0005669transcription factor TFIID complex
CCIDAGO:0005794Golgi apparatus
MFIBAGO:0003713transcription coactivator activity
MFIDAGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0042809vitamin D receptor binding
MFIPIGO:0046966thyroid hormone receptor binding
MFIEAGO:0046982protein heterodimerization activity
MFIPIGO:0047485protein N-terminus binding

Gene expression in normal tissue: TAF11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAF11


DatabasePathway IDPathway Des.
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-1643685Disease
reactomeR-HSA-167161HIV Transcription Initiation
reactomeR-HSA-167162RNA Polymerase II HIV Promoter Escape
reactomeR-HSA-167172Transcription of the HIV genome
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-674695RNA Polymerase II Pre-transcription Events
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-6807505RNA polymerase II transcribes snRNA genes
reactomeR-HSA-73776RNA Polymerase II Promoter Escape
reactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75953RNA Polymerase II Transcription Initiation
reactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter Clearance
kegghsa03022Basal transcription factors - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAF11

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