ZEB1


Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in ZEB1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF IEA GO:0003682 chromatin binding
MF TAS GO:0003700 DNA-binding transcription factor activity
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Gene expression in normal tissue: ZEB1

Gene-model tissue-cancer distribution: Bubble Plot

LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Mantle Cell Lymphoma (MCL) model num: 5

Gene-drug pathway distribution

DNA replication2Purine metabolism1undefined1

Pathways in ZEB1


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Database
Pathway ID
Pathway Des.
pid ilk_pathway Integrin-linked kinase signaling
netpath Pathway_TGF_beta_Receptor TGF_beta_Receptor
pharmgkb PA165984799 Diuretics Pathway, Pharmacodynamics
kegg hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
kegg hsa05206 MicroRNAs in cancer - Homo sapiens (human)
kegg hsa05215 Prostate cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD66 Doxorubicin 2
iGMDRD529 Salinomycin 1
iGMDRD79 Gemcitabine 1
iGMDRD50 Cytarabine 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ZEB1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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