ZEB1
Summary: This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:189909 Ensembl IDEnsembl:ENSG00000148516 HGNC IDHGNC:HGNC:11642 PHARMGKB IDPA162409589 Map Location10p11.22 |
GO terms in ZEB1
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
MF | IEA | GO:0003682 | chromatin binding |
MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
Gene expression in normal tissue: ZEB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ZEB1
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | ilk_pathway | Integrin-linked kinase signaling |
netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in ZEB1
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |