TCN1

Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametranscobalamin 1
OMIM IDMIM:189905
Ensembl IDEnsembl:ENSG00000134827
HGNC IDHGNC:HGNC:11652
PHARMGKB IDPA36403
Map Location11q12.1

Gene Categories:

DRUGGABLE GENOME

GO terms in TCN1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0031419 cobalamin binding
BP IEA GO:0006824 cobalt ion transport
BP TAS GO:0009235 cobalamin metabolic process
BP IEA GO:0015889 cobalamin transport
BP TAS GO:0043312 neutrophil degranulation
CC TAS GO:0005576 extracellular region
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Gene expression in normal tissue: TCN1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in TCN1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
reactome R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
reactome R-HSA-196854 Metabolism of vitamins and cofactors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

KRASKRASZNF273ZNF273PAX5PAX5CCDC117CCDC117SLC16A3SLC16A3NPAS2NPAS2RXRARXRAZFP36L2ZFP36L2RNU2-11PRNU2-11PAPOC1APOC1TCF7L2TCF7L2ZNF682ZNF682BRAFBRAFWDR24WDR24FERMT1FERMT1NHLRC1NHLRC1ZNF736ZNF736RN7SL477PRN7SL477PNRASNRASKLHL32KLHL32PD0325901PD0325901TCN1TCN1

Gene-drug targets distribution

Gene Structure: PDB

Models in TCN1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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