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TCN1

Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
transcobalamin 1	MIM:189905	Ensembl:ENSG00000134827	HGNC:HGNC:11652	PA36403	11q12.1

Gene Categories:

DRUGGABLE GENOME

GO terms in TCN1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0031419	cobalamin binding
BP	IEA	GO:0006824	cobalt ion transport
BP	TAS	GO:0009235	cobalamin metabolic process
BP	IEA	GO:0015889	cobalamin transport
BP	TAS	GO:0043312	neutrophil degranulation
CC	TAS	GO:0005576	extracellular region
CC	HDA	GO:0005615	extracellular space
CC	TAS	GO:0035580	specific granule lumen
CC	TAS	GO:1904724	tertiary granule lumen

Gene expression in normal tissue: TCN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TCN1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism
reactome	R-HSA-196849	Metabolism of water-soluble vitamins and cofactors
reactome	R-HSA-196854	Metabolism of vitamins and cofactors
reactome	R-HSA-6798695	Neutrophil degranulation
wikipathways	WP1533	Vitamin B12 Metabolism

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TCN1

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CLASSFICATION

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