DYNLT3

Summary: This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namedynein light chain Tctex-type 3
OMIM IDMIM:300302
Ensembl IDEnsembl:ENSG00000165169
HGNC IDHGNC:HGNC:11694
PHARMGKB IDPA36414
Map LocationXp11.4

Gene Categories:

TUMOR SUPPRESSOR

GO terms in DYNLT3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003774 motor activity
MF IPI GO:0005515 protein binding
MF IPI GO:0042802 identical protein binding
CC IDA GO:0000776 kinetochore
CC IEA GO:0000777 condensed chromosome kinetochore
CC IEA GO:0005634 nucleus
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Gene expression in normal tissue: DYNLT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DYNLT3


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DYNLT3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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