TDO2
Summary: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:191070 Ensembl IDEnsembl:ENSG00000151790 HGNC IDHGNC:HGNC:11708 PHARMGKB IDPA36427 Map Location4q32.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in TDO2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004833 | tryptophan 2,3-dioxygenase activity |
| MF | IDA | GO:0004833 | tryptophan 2,3-dioxygenase activity |
| MF | TAS | GO:0004833 | tryptophan 2,3-dioxygenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016597 | amino acid binding |
| MF | IEA | GO:0019825 | oxygen binding |
Gene expression in normal tissue: TDO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TDO2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-6788656 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism |
| reactome | R-HSA-71240 | Tryptophan catabolism |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| humancyc | NADSYN-PWY | NAD de novo biosynthesis |
| humancyc | PWY-5651 | tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TDO2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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