TDO2
Summary: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tryptophan 2,3-dioxygenase | MIM:191070 | Ensembl:ENSG00000151790 | HGNC:HGNC:11708 | PA36427 | 4q32.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TDO2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004833 | tryptophan 2,3-dioxygenase activity |
| MF | IDA | GO:0004833 | tryptophan 2,3-dioxygenase activity |
| MF | TAS | GO:0004833 | tryptophan 2,3-dioxygenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016597 | amino acid binding |
| MF | IEA | GO:0019825 | oxygen binding |
| MF | IBA | GO:0020037 | heme binding |
| MF | IDA | GO:0020037 | heme binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | TAS | GO:0006569 | tryptophan catabolic process |
| BP | IDA | GO:0019441 | tryptophan catabolic process to kynurenine |
| BP | IEA | GO:0019441 | tryptophan catabolic process to kynurenine |
| BP | IBA | GO:0019442 | tryptophan catabolic process to acetyl-CoA |
| BP | IDA | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: TDO2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TDO2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-6788656 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism |
| reactome | R-HSA-71240 | Tryptophan catabolism |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| humancyc | NADSYN-PWY | NAD de novo biosynthesis |
| humancyc | PWY-5651 | tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde |
| humancyc | PWY-6309 | L-kynurenine degradation |
| humancyc | PWY66-401 | superpathway of tryptophan utilization |
| humancyc | TRYPTOPHAN-DEGRADATION-1 | tryptophan degradation |
| kegg | hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| smpdb | SMP00063 | Tryptophan Metabolism |
| wikipathways | WP2485 | NAD Biosynthesis II (from tryptophan) |
| wikipathways | WP3645 | NAD+ biosynthetic pathways |
| wikipathways | WP3925 | Amino Acid metabolism |
| wikipathways | WP465 | Tryptophan metabolism |
| wikipathways | WP727 | Monoamine Transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TDO2
CLASSFICATION
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