Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].

telomerase reverse transcriptaseMIM:187270Ensembl:ENSG00000164362HGNC:HGNC:11730PA364475p15.33

GO terms in TERT

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000723telomere maintenance
BPIDAGO:0001172transcription, RNA-templated
BPIDAGO:0006278RNA-dependent DNA biosynthetic process
BPIBAGO:0007004telomere maintenance via telomerase
BPIDAGO:0007004telomere maintenance via telomerase
BPIMPGO:0007004telomere maintenance via telomerase
BPNASGO:0007004telomere maintenance via telomerase
BPTASGO:0007004telomere maintenance via telomerase
BPIDAGO:0007005mitochondrion organization
BPIDAGO:0010629negative regulation of gene expression
BPIDAGO:0022616DNA strand elongation
BPIGIGO:0030177positive regulation of Wnt signaling pathway
BPIDAGO:0030422production of siRNA involved in RNA interference
BPIDAGO:0031647regulation of protein stability
BPIMPGO:0031647regulation of protein stability
BPIDAGO:0032092positive regulation of protein binding
BPIDAGO:0032774RNA biosynthetic process
BPISSGO:0042635positive regulation of hair cycle
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0045766positive regulation of angiogenesis
BPIEAGO:0046326positive regulation of glucose import
BPIEAGO:0046686response to cadmium ion
BPIDAGO:0051000positive regulation of nitric-oxide synthase activity
BPIEAGO:0060253negative regulation of glial cell proliferation
BPIDAGO:0070200establishment of protein localization to telomere
BPIMPGO:0071456cellular response to hypoxia
BPIDAGO:0071897DNA biosynthetic process
BPIMPGO:0090399replicative senescence
BPIEAGO:1900087positive regulation of G1/S transition of mitotic cell cycle
BPIMPGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIEAGO:1903620positive regulation of transdifferentiation
BPIDAGO:1903704negative regulation of production of siRNA involved in RNA interference
BPIEAGO:1904707positive regulation of vascular smooth muscle cell proliferation
BPIDAGO:1904751positive regulation of protein localization to nucleolus
BPIEAGO:1904754positive regulation of vascular associated smooth muscle cell migration
BPTASGO:1904837beta-catenin-TCF complex assembly
BPIEAGO:2000352negative regulation of endothelial cell apoptotic process
BPISSGO:2000648positive regulation of stem cell proliferation
BPIDAGO:2000773negative regulation of cellular senescence
BPIMPGO:2000773negative regulation of cellular senescence
BPIMPGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCIBAGO:0000333telomerase catalytic core complex
CCIDAGO:0000333telomerase catalytic core complex
CCIMPGO:0000333telomerase catalytic core complex
CCIPIGO:0000333telomerase catalytic core complex
CCICGO:0000781chromosome, telomeric region
CCICGO:0000783nuclear telomere cap complex
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0005697telomerase holoenzyme complex
CCIPIGO:0005697telomerase holoenzyme complex
CCTASGO:0005697telomerase holoenzyme complex
CCIEAGO:0005886plasma membrane
CCIDAGO:0016605PML body
CCIDAGO:0016607nuclear speck
CCIPIGO:0031379RNA-directed RNA polymerase complex
CCIDAGO:0042645mitochondrial nucleoid
CCIDAGO:1990572TERT-RMRP complex
MFIDAGO:0000049tRNA binding
MFIPIGO:0001223transcription coactivator binding
MFIDAGO:0003677DNA binding
MFIDAGO:0003720telomerase activity
MFTASGO:0003720telomerase activity
MFIBAGO:0003721telomerase RNA reverse transcriptase activity
MFIDAGO:0003721telomerase RNA reverse transcriptase activity
MFIMPGO:0003721telomerase RNA reverse transcriptase activity
MFTASGO:0003721telomerase RNA reverse transcriptase activity
MFIPIGO:0003723RNA binding
MFIDAGO:0003964RNA-directed DNA polymerase activity
MFTASGO:0003964RNA-directed DNA polymerase activity
MFIDAGO:0003968RNA-directed 5'-3' RNA polymerase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFIDAGO:0016779nucleotidyltransferase activity
MFIBAGO:0042162telomeric DNA binding
MFTASGO:0042162telomeric DNA binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding
MFIPIGO:0047485protein N-terminus binding
MFIPIGO:0051087chaperone binding
MFIBAGO:0070034telomerase RNA binding
MFIDAGO:0070034telomerase RNA binding
MFIPIGO:0070034telomerase RNA binding
MFIDAGO:0098680template-free RNA nucleotidyltransferase

Gene expression in normal tissue: TERT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TERT

DatabasePathway IDPathway Des.
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartatelpathwaytelomeres telomerase cellular aging and immortality
biocartatertpathwayoverview of telomerase protein component gene htert transcriptional regulation
reactomeR-HSA-157579Telomere Maintenance
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-171319Telomere Extension By Telomerase
reactomeR-HSA-180786Extension of Telomeres
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-73886Chromosome Maintenance
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP366TGF-beta Signaling Pathway
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidtelomerasepathwayRegulation of Telomerase
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD163all trans Retinoic Acid1
iGMDRD61Kinetin riboside4
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TERT