TFDP2

Summary: The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametranscription factor Dp-2
OMIM IDMIM:602160
Ensembl IDEnsembl:ENSG00000114126
HGNC IDHGNC:HGNC:11751
PHARMGKB IDPA36466
Map Location3q23

GO terms in TFDP2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0005739 mitochondrion
CC IDA GO:0090575 RNA polymerase II transcription factor complex
BP TAS GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
BP IBA GO:0006357 regulation of transcription by RNA polymerase II
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Gene expression in normal tissue: TFDP2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in TFDP2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109581 Apoptosis
reactome R-HSA-109606 Intrinsic Pathway for Apoptosis
reactome R-HSA-111448 Activation of NOXA and translocation to mitochondria
reactome R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactome R-HSA-113510 E2F mediated regulation of DNA replication
reactome R-HSA-114452 Activation of BH3-only proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

KRASKRASZNF273ZNF273PAX5PAX5CCDC117CCDC117SLC16A3SLC16A3NPAS2NPAS2RXRARXRAZFP36L2ZFP36L2RNU2-11PRNU2-11PAPOC1APOC1TCF7L2TCF7L2ZNF682ZNF682BRAFBRAFWDR24WDR24FERMT1FERMT1NHLRC1NHLRC1ZNF736ZNF736RN7SL477PRN7SL477PNRASNRASKLHL32KLHL32PD0325901PD0325901TFDP2TFDP2

Gene-drug targets distribution

Gene Structure: PDB

Models in TFDP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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