Summary: This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016].

tissue factor pathway inhibitorMIM:152310Ensembl:ENSG00000003436HGNC:HGNC:11760PA364752q32.1

GO terms in TFPI

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004866endopeptidase inhibitor activity
MFIBAGO:0004867serine-type endopeptidase inhibitor activity
MFIEAGO:0004867serine-type endopeptidase inhibitor activity
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIEAGO:0005783endoplasmic reticulum
CCTASGO:0005886plasma membrane
CCHDAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIEAGO:0031090organelle membrane
CCIEAGO:0031225anchored component of membrane
BPTASGO:0007596blood coagulation
BPTASGO:0007598blood coagulation, extrinsic pathway
BPIEAGO:0010951negative regulation of endopeptidase activity
BPIDAGO:0030195negative regulation of blood coagulation
BPIEAGO:0032355response to estradiol
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:0071347cellular response to interleukin-1
BPIEPGO:0071383cellular response to steroid hormone stimulus

Gene expression in normal tissue: TFPI

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TFPI

DatabasePathway IDPathway Des.
biocartaextrinsicpathwayextrinsic prothrombin activation pathway
reactomeR-HSA-140834Extrinsic Pathway of Fibrin Clot Formation
reactomeR-HSA-140877Formation of Fibrin Clot (Clotting Cascade)
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP3896Dengue-2 Interactions with Complement and Coagulation Cascades
wikipathwaysWP558Complement and Coagulation Cascades
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
pidsyndecan_4_pathwaySyndecan-4-mediated signaling events

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TFPI