TFPI
Summary: This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:152310 Ensembl IDEnsembl:ENSG00000003436 HGNC IDHGNC:HGNC:11760 PHARMGKB IDPA36475 Map Location2q32.1 | |||||
GO terms in TFPI
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004866 | endopeptidase inhibitor activity |
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IEA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
Gene expression in normal tissue: TFPI
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFPI
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | extrinsicpathway | extrinsic prothrombin activation pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-140834 | Extrinsic Pathway of Fibrin Clot Formation |
| reactome | R-HSA-140877 | Formation of Fibrin Clot (Clotting Cascade) |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP3896 | Dengue-2 Interactions with Complement and Coagulation Cascades |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFPI
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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