Summary: This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

transforming growth factor alphaMIM:190170Ensembl:ENSG00000163235HGNC:HGNC:11765PA364802p13.3

GO terms in TGFA

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005154epidermal growth factor receptor binding
MFIDAGO:0005154epidermal growth factor receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIDAGO:0008083growth factor activity
BPIBAGO:0000187activation of MAPK activity
BPIDAGO:0000187activation of MAPK activity
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIBAGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0008283cell proliferation
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0045741positive regulation of epidermal growth factor-activated receptor activity
BPIDAGO:0045840positive regulation of mitotic nuclear division
BPTASGO:0048208COPII vesicle coating
BPIDAGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0051781positive regulation of cell division
CCIEAGO:0000139Golgi membrane
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0005789endoplasmic reticulum membrane
CCNASGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0012507ER to Golgi transport vesicle membrane
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0031410cytoplasmic vesicle
CCTASGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane
CCIDAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: TGFA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFA

DatabasePathway IDPathway Des.
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
piderbb_network_pathwayErbB receptor signaling network
pidfoxm1pathwayFOXM1 transcription factor network
pidp53downstreampathwayDirect p53 effectors
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP3927BMP Signaling Pathway in Eyelid Development
wikipathwaysWP4086Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
wikipathwaysWP673ErbB Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5694530Cargo concentration in the ER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
reactomeR-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFA