TGFA
Summary: This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:190170 Ensembl IDEnsembl:ENSG00000163235 HGNC IDHGNC:HGNC:11765 PHARMGKB IDPA36480 Map Location2p13.3 | |||||
GO terms in TGFA
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IDA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0008083 | growth factor activity |
| BP | IBA | GO:0000187 | activation of MAPK activity |
Gene expression in normal tissue: TGFA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TGFA
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TGFA
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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