Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016].

transforming growth factor beta 3MIM:190230Ensembl:ENSG00000119699HGNC:HGNC:11769PA3648314q24.3

GO terms in TGFB3

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCICGO:0005886plasma membrane
CCIEAGO:0009986cell surface
CCTASGO:0031093platelet alpha granule lumen
CCIEAGO:0043025neuronal cell body
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0062023collagen-containing extracellular matrix
BPIEAGO:0000187activation of MAPK activity
BPIDAGO:0001666response to hypoxia
BPISSGO:0001701in utero embryonic development
BPTASGO:0002576platelet degranulation
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEPGO:0007435salivary gland morphogenesis
BPIEAGO:0007565female pregnancy
BPIMPGO:0008284positive regulation of cell proliferation
BPIMPGO:0008285negative regulation of cell proliferation
BPISSGO:0008285negative regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010718positive regulation of epithelial to mesenchymal transition
BPISSGO:0010718positive regulation of epithelial to mesenchymal transition
BPIBAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPISSGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0010936negative regulation of macrophage cytokine production
BPIEPGO:0030501positive regulation of bone mineralization
BPIEAGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPISSGO:0030879mammary gland development
BPIDAGO:0032570response to progesterone
BPIMPGO:0032967positive regulation of collagen biosynthetic process
BPIEAGO:0034616response to laminar fluid shear stress
BPIEAGO:0042060wound healing
BPIBAGO:0042127regulation of cell proliferation
BPTASGO:0042704uterine wall breakdown
BPIBAGO:0042981regulation of apoptotic process
BPISSGO:0043065positive regulation of apoptotic process
BPIBAGO:0043408regulation of MAPK cascade
BPISSGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0043627response to estrogen
BPIEPGO:0043932ossification involved in bone remodeling
BPIDAGO:0045216cell-cell junction organization
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0048286lung alveolus development
BPIBAGO:0048468cell development
BPIEAGO:0048565digestive tract development
BPIEAGO:0048702embryonic neurocranium morphogenesis
BPIEAGO:0048839inner ear development
BPIDAGO:0050714positive regulation of protein secretion
BPISSGO:0051491positive regulation of filopodium assembly
BPIDAGO:0051496positive regulation of stress fiber assembly
BPIEAGO:0051781positive regulation of cell division
BPIMPGO:0060325face morphogenesis
BPIEAGO:0060364frontal suture morphogenesis
BPISSGO:0060391positive regulation of SMAD protein signal transduction
BPIBAGO:0060395SMAD protein signal transduction
BPISSGO:0062009secondary palate development
BPIDAGO:0070483detection of hypoxia
BPIDAGO:1904706negative regulation of vascular smooth muscle cell proliferation
BPISSGO:1905005regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BPIDAGO:1905075positive regulation of occluding junction disassembly
MFIBAGO:0005114type II transforming growth factor beta receptor binding
MFIDAGO:0005114type II transforming growth factor beta receptor binding
MFIMPGO:0005114type II transforming growth factor beta receptor binding
MFIPIGO:0005114type II transforming growth factor beta receptor binding
MFIBAGO:0005125cytokine activity
MFIBAGO:0005160transforming growth factor beta receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIDAGO:0034713type I transforming growth factor beta receptor binding
MFIMPGO:0034714type III transforming growth factor beta receptor binding
MFIDAGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0046982protein heterodimerization activity
MFIDAGO:0050431transforming growth factor beta binding

Gene expression in normal tissue: TGFB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFB3

DatabasePathway IDPathway Des.
biocartaalkpathwayalk in cardiac myocytes
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartail1rpathwaysignal transduction through il1r
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartatgfbpathwaytgf beta signaling pathway
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3655Hypothetical Craniofacial Development Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP4241Type 2 papillary renal cell carcinoma
pidalk1pathwayALK1 signaling events
pidglypican_1pathwayGlypican 1 network
pidtgfbrpathwayTGF-beta receptor signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05144Malaria - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD163all trans Retinoic Acid3
iGMDRD730Kahalalide F3
iGMDRD887Compound 23 citrate3
iGMDRD85Ursolic acid3
iGMDRD584VER 1550083
iGMDRD512nutlin 34
iGMDRD607Ubistatin B3
iGMDRD286Nsc 6328393
iGMDRD5Tyrphostin AG 14781
iGMDRD271Brefeldin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFB3