TGFBR2


Summary: The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transforming growth factor beta receptor 2MIM:190182Ensembl:ENSG00000163513HGNC:HGNC:11773PA364863p24.1

GO terms in TGFBR2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0001568blood vessel development
BPISSGO:0001569branching involved in blood vessel morphogenesis
BPISSGO:0001570vasculogenesis
BPIEAGO:0001666response to hypoxia
BPIEAGO:0001701in utero embryonic development
BPISSGO:0001947heart looping
BPISSGO:0002053positive regulation of mesenchymal cell proliferation
BPIEAGO:0002088lens development in camera-type eye
BPISSGO:0002651positive regulation of tolerance induction to self antigen
BPISSGO:0002663positive regulation of B cell tolerance induction
BPISSGO:0002666positive regulation of T cell tolerance induction
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003149membranous septum morphogenesis
BPISSGO:0003151outflow tract morphogenesis
BPISSGO:0003181atrioventricular valve morphogenesis
BPISSGO:0003186tricuspid valve morphogenesis
BPISSGO:0003214cardiac left ventricle morphogenesis
BPISSGO:0003274endocardial cushion fusion
BPIEAGO:0003430growth plate cartilage chondrocyte growth
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006898receptor-mediated endocytosis
BPIDAGO:0006915apoptotic process
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPICGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPIMPGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007182common-partner SMAD protein phosphorylation
BPIEAGO:0007219Notch signaling pathway
BPIEAGO:0007224smoothened signaling pathway
BPIEAGO:0007369gastrulation
BPIBAGO:0007389pattern specification process
BPISSGO:0007420brain development
BPIBAGO:0007507heart development
BPISSGO:0007507heart development
BPIEAGO:0007566embryo implantation
BPIEAGO:0007568aging
BPIEAGO:0007584response to nutrient
BPTASGO:0008284positive regulation of cell proliferation
BPIEAGO:0009612response to mechanical stimulus
BPIEAGO:0009749response to glucose
BPIEAGO:0010468regulation of gene expression
BPIEAGO:0010634positive regulation of epithelial cell migration
BPIDAGO:0010718positive regulation of epithelial to mesenchymal transition
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPTASGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIEAGO:0031100animal organ regeneration
BPISSGO:0032147activation of protein kinase activity
BPIBAGO:0032924activin receptor signaling pathway
BPISSGO:0035162embryonic hemopoiesis
BPIEAGO:0042060wound healing
BPISSGO:0042127regulation of cell proliferation
BPIDAGO:0042493response to drug
BPISSGO:0043011myeloid dendritic cell differentiation
BPIEAGO:0043415positive regulation of skeletal muscle tissue regeneration
BPIEAGO:0043627response to estrogen
BPIEAGO:0045766positive regulation of angiogenesis
BPIEAGO:0048545response to steroid hormone
BPIEAGO:0048565digestive tract development
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPISSGO:0048701embryonic cranial skeleton morphogenesis
BPISSGO:0051138positive regulation of NK T cell differentiation
BPIEAGO:0060044negative regulation of cardiac muscle cell proliferation
BPIDAGO:0060389pathway-restricted SMAD protein phosphorylation
BPISSGO:0060412ventricular septum morphogenesis
BPIEAGO:0060434bronchus morphogenesis
BPIEAGO:0060440trachea formation
BPIEAGO:0060443mammary gland morphogenesis
BPIEAGO:0060463lung lobe morphogenesis
BPISSGO:0062009secondary palate development
BPIDAGO:0070723response to cholesterol
BPISSGO:1905007positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BPISSGO:1905315cell proliferation involved in endocardial cushion morphogenesis
BPISSGO:1905316superior endocardial cushion morphogenesis
BPISSGO:1905317inferior endocardial cushion morphogenesis
BPIEAGO:1990086lens fiber cell apoptotic process
BPISSGO:1990428miRNA transport
BPIMPGO:2000379positive regulation of reactive oxygen species metabolic process
BPIDAGO:2000563positive regulation of CD4-positive, alpha-beta T cell proliferation
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005901caveola
CCIDAGO:0009897external side of plasma membrane
CCIDAGO:0016021integral component of membrane
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCIDAGO:0045121membrane raft
CCIBAGO:0048179activin receptor complex
CCICGO:0070022transforming growth factor beta receptor complex
MFIDAGO:0004675transmembrane receptor protein serine/threonine kinase activity
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFICGO:0005024transforming growth factor beta-activated receptor activity
MFIDAGO:0005024transforming growth factor beta-activated receptor activity
MFIMPGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005026transforming growth factor beta receptor activity, type II
MFIEAGO:0005026transforming growth factor beta receptor activity, type II
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0005539glycosaminoglycan binding
MFIBAGO:0019838growth factor binding
MFIEAGO:0031435mitogen-activated protein kinase kinase kinase binding
MFIBAGO:0034713type I transforming growth factor beta receptor binding
MFIPIGO:0034713type I transforming growth factor beta receptor binding
MFIBAGO:0046332SMAD binding
MFIDAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0048185activin binding
MFIDAGO:0050431transforming growth factor beta binding
MFIPIGO:0050431transforming growth factor beta binding
MFIPIGO:0050431transforming growth factor beta binding

Gene expression in normal tissue: TGFBR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGFBR2


DatabasePathway IDPathway Des.
wikipathwaysWP2001miR-targeted genes in adipocytes - TarBase
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3874Canonical and Non-Canonical TGF-B signaling
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP560TGF-beta Receptor Signaling
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidalk1pathwayALK1 signaling events
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidglypican_1pathwayGlypican 1 network
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidtgfbrpathwayTGF-beta receptor signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
biocartaalkpathwayalk in cardiac myocytes
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartatgfbpathwaytgf beta signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactomeR-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactomeR-HSA-3304349Loss of Function of SMAD2/3 in Cancer
reactomeR-HSA-3304351Signaling by TGF-beta Receptor Complex in Cancer
reactomeR-HSA-3304356SMAD2/3 Phosphorylation Motif Mutants in Cancer
reactomeR-HSA-3315487SMAD2/3 MH2 Domain Mutants in Cancer
reactomeR-HSA-3642278Loss of Function of TGFBR2 in Cancer
reactomeR-HSA-3642279TGFBR2 MSI Frameshift Mutants in Cancer
reactomeR-HSA-3645790TGFBR2 Kinase Domain Mutants in Cancer
reactomeR-HSA-3656532TGFBR1 KD Mutants in Cancer
reactomeR-HSA-3656534Loss of Function of TGFBR1 in Cancer
reactomeR-HSA-3656535TGFBR1 LBD Mutants in Cancer
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689603UCH proteinases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD874BRD89582
iGMDRD398Sepantronium2
iGMDRD318PAC-13
iGMDRD260FQI-23
iGMDRD138PX 126
iGMDRD474Avrainvillamide4
iGMDRD280CYTOCHALASIN B6
iGMDRD394BX-7953
iGMDRD679Bistramide A3
iGMDRD639YK 4-2792
iGMDRD61Kinetin riboside1
iGMDRD152179324-69-72
iGMDRD494Neopeltolide2
iGMDRD599Salermide2
iGMDRD387CHIR-990211
iGMDRD151CHM-13
iGMDRD554CHEMBL14341372
iGMDRD433Lexibulin3
iGMDRD353PD03259012
iGMDRD82Quiflapon2
iGMDRD246NPC263
iGMDRD366PI-1032
iGMDRD367Ro 28-16753
iGMDRD871BRD63681
iGMDRD872BRD71374
iGMDRD77Itraconazole2
iGMDRD231Importazole1
iGMDRD6AM-5803
iGMDRD434BMS-5369242
iGMDRD202Curcumin4
iGMDRD158NSC1415404
iGMDRD154NSC237662
iGMDRD211(1S,3R)-RSL31
iGMDRD57Chloropentafluorobenzene4
iGMDRD314Tanespimycin4
iGMDRD79Gemcitabine3
iGMDRD512nutlin 31
iGMDRD84Lovastatin acid2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGFBR2

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