Summary: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

transglutaminase 2MIM:190196Ensembl:ENSG00000198959HGNC:HGNC:11778PA3649120q11.23

Gene Categories:


GO terms in TGM2

Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005783endoplasmic reticulum
CCHDAGO:0005925focal adhesion
CCIDAGO:0031226intrinsic component of plasma membrane
CCIMPGO:0031226intrinsic component of plasma membrane
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001974blood vessel remodeling
BPIEAGO:0018153isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
BPIMPGO:0032471negative regulation of endoplasmic reticulum calcium ion concentration
BPIMPGO:0043065positive regulation of apoptotic process
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043277apoptotic cell clearance
BPISSGO:0045785positive regulation of cell adhesion
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPIEAGO:0050729positive regulation of inflammatory response
BPIEAGO:0051260protein homooligomerization
BPIEAGO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
BPIMPGO:0051561positive regulation of mitochondrial calcium ion concentration
BPIEAGO:0060445branching involved in salivary gland morphogenesis
BPIEAGO:0060662salivary gland cavitation
MFIMPGO:0003810protein-glutamine gamma-glutamyltransferase activity
MFISSGO:0003810protein-glutamine gamma-glutamyltransferase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIEAGO:0019904protein domain specific binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: TGM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TGM2

DatabasePathway IDPathway Des.
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
kegghsa05016Huntington,s disease - Homo sapiens (human)
biocartaplcdpathwayphospholipase c delta in phospholipid associated cell signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TGM2