TSPO
Summary: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:109610 Ensembl IDEnsembl:ENSG00000100300 HGNC IDHGNC:HGNC:1158 PHARMGKB IDPA25473 Map Location22q13.2 | |||||
GO terms in TSPO
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043229 | intracellular organelle |
Gene expression in normal tissue: TSPO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TSPO
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pharmgkb | PA165111376 | Benzodiazepine Pathway, Pharmacodynamics |
| reactome | R-HSA-1430728 | Metabolism |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TSPO
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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