Summary: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012].

translocator proteinMIM:109610Ensembl:ENSG00000100300HGNC:HGNC:1158PA2547322q13.2

GO terms in TSPO

Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
CCIBAGO:0005783endoplasmic reticulum
CCIBAGO:0016021integral component of membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0043229intracellular organelle
CCHDAGO:0070062extracellular exosome
BPTASGO:0006626protein targeting to mitochondrion
BPTASGO:0006700C21-steroid hormone biosynthetic process
BPTASGO:0006783heme biosynthetic process
BPTASGO:0006820anion transport
BPIEAGO:0006821chloride transport
BPTASGO:0006915apoptotic process
BPIEAGO:0007165signal transduction
BPTASGO:0008202steroid metabolic process
BPTASGO:0008283cell proliferation
BPIEAGO:0008347glial cell migration
BPIEAGO:0010042response to manganese ion
BPIEAGO:0010266response to vitamin B1
BPIEAGO:0010940positive regulation of necrotic cell death
BPIEAGO:0014012peripheral nervous system axon regeneration
BPIEAGO:0030301cholesterol transport
BPIEAGO:0030325adrenal gland development
BPIEAGO:0031397negative regulation of protein ubiquitination
BPTASGO:0032374regulation of cholesterol transport
BPIEAGO:0032570response to progesterone
BPIEAGO:0032720negative regulation of tumor necrosis factor production
BPIEAGO:0033574response to testosterone
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0045019negative regulation of nitric oxide biosynthetic process
BPIEAGO:0048266behavioral response to pain
BPIEAGO:0050810regulation of steroid biosynthetic process
BPIEAGO:0051901positive regulation of mitochondrial depolarization
BPIEAGO:0051928positive regulation of calcium ion transport
BPIEAGO:0060242contact inhibition
BPIEAGO:0060252positive regulation of glial cell proliferation
BPIEAGO:0060253negative regulation of glial cell proliferation
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:0071294cellular response to zinc ion
BPIEAGO:0071476cellular hypotonic response
BPIEAGO:0072656maintenance of protein location in mitochondrion
BPIEAGO:1903147negative regulation of autophagy of mitochondrion
BPIEAGO:1903579negative regulation of ATP metabolic process
BPIEAGO:2000379positive regulation of reactive oxygen species metabolic process
MFIEAGO:0005497androgen binding
MFIPIGO:0005515protein binding
MFIEAGO:0008503benzodiazepine receptor activity
MFIBAGO:0015485cholesterol binding
MFTASGO:0015485cholesterol binding
MFTASGO:0017127cholesterol transporter activity
MFIEAGO:0044325ion channel binding

Gene expression in normal tissue: TSPO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TSPO

DatabasePathway IDPathway Des.
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04979Cholesterol metabolism - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
pharmgkbPA165111376Benzodiazepine Pathway, Pharmacodynamics
reactomeR-HSA-196071Metabolism of steroid hormones
reactomeR-HSA-196108Pregnenolone biosynthesis
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8957322Metabolism of steroids

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TSPO