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TIAM1

Summary: This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
T cell lymphoma invasion and metastasis 1	MIM:600687	Ensembl:ENSG00000156299	HGNC:HGNC:11805	PA36514	21q22.11

Gene Categories:

KINASE SERINE THREONINE KINASE

GO terms in TIAM1

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0005634	nucleus
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005874	microtubule
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0005911	cell-cell junction
CC	IEA	GO:0014069	postsynaptic density
CC	IDA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	IEA	GO:0032587	ruffle membrane
CC	IEA	GO:0043025	neuronal cell body
CC	IEA	GO:0043197	dendritic spine
CC	IDA	GO:0044291	cell-cell contact zone
CC	IEA	GO:0044295	axonal growth cone
CC	IEA	GO:0044304	main axon
BP	IEA	GO:0003300	cardiac muscle hypertrophy
BP	IEA	GO:0006915	apoptotic process
BP	IMP	GO:0007160	cell-matrix adhesion
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway
BP	IDA	GO:0008284	positive regulation of cell proliferation
BP	IDA	GO:0010717	regulation of epithelial to mesenchymal transition
BP	NAS	GO:0010718	positive regulation of epithelial to mesenchymal transition
BP	IMP	GO:0016477	cell migration
BP	IMP	GO:0016601	Rac protein signal transduction
BP	IDA	GO:0030335	positive regulation of cell migration
BP	IDA	GO:0032092	positive regulation of protein binding
BP	IEA	GO:0035023	regulation of Rho protein signal transduction
BP	IEA	GO:0042220	response to cocaine
BP	TAS	GO:0043065	positive regulation of apoptotic process
BP	IEA	GO:0043507	positive regulation of JUN kinase activity
BP	TAS	GO:0048013	ephrin receptor signaling pathway
BP	IEA	GO:0050772	positive regulation of axonogenesis
BP	TAS	GO:0051056	regulation of small GTPase mediated signal transduction
BP	NAS	GO:0060071	Wnt signaling pathway, planar cell polarity pathway
BP	IEA	GO:0061003	positive regulation of dendritic spine morphogenesis
BP	IEA	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
BP	IEA	GO:0070372	regulation of ERK1 and ERK2 cascade
BP	IEA	GO:0072657	protein localization to membrane
BP	IDA	GO:0090630	activation of GTPase activity
BP	IEA	GO:0098989	NMDA selective glutamate receptor signaling pathway
BP	IEA	GO:1904268	positive regulation of Schwann cell chemotaxis
BP	ISS	GO:1904338	regulation of dopaminergic neuron differentiation
BP	IEA	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton
BP	IEA	GO:1990138	neuron projection extension
BP	ISS	GO:2000050	regulation of non-canonical Wnt signaling pathway
MF	EXP	GO:0005085	guanyl-nucleotide exchange factor activity
MF	TAS	GO:0005085	guanyl-nucleotide exchange factor activity
MF	TAS	GO:0005089	Rho guanyl-nucleotide exchange factor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008017	microtubule binding
MF	IEA	GO:0008289	lipid binding
MF	IPI	GO:0019900	kinase binding
MF	IDA	GO:0030676	Rac guanyl-nucleotide exchange factor activity
MF	IMP	GO:0030676	Rac guanyl-nucleotide exchange factor activity
MF	IEA	GO:0030971	receptor tyrosine kinase binding

Gene expression in normal tissue: TIAM1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIAM1

Database	Pathway ID	Pathway Des.
wikipathways	WP2038	Regulation of Microtubule Cytoskeleton
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP4180	Ebola Virus Pathway on Host
wikipathways	WP4217	Ebola Virus Pathway on Host
wikipathways	WP4223	Ras Signaling
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
pid	arf6downstreampathway	Arf6 downstream pathway
pid	cdc42_pathway	CDC42 signaling events
pid	ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction
pid	epha2_fwdpathway	EPHA2 forward signaling
pid	ephrinbrevpathway	Ephrin B reverse signaling
pid	lysophospholipid_pathway	LPA receptor mediated events
pid	rac1_reg_pathway	Regulation of RAC1 activity
pid	trkrpathway	Neurotrophic factor-mediated Trk receptor signaling
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04024	cAMP signaling pathway - Homo sapiens (human)
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04530	Tight junction - Homo sapiens (human)
kegg	hsa04810	Regulation of actin cytoskeleton - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-193648	NRAGE signals death through JNK
reactome	R-HSA-193704	p75 NTR receptor-mediated signalling
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-194840	Rho GTPase cycle
reactome	R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-3928662	EPHB-mediated forward signaling
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-416482	G alpha (12/13) signalling events
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-73887	Death Receptor Signalling
reactome	R-HSA-9006115	Signaling by NTRK2 (TRKB)
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9032845	Activated NTRK2 signals through CDK5

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD398	Sepantronium	2
iGMDRD562	Navitoclax	1
iGMDRD780	PP-30	1
iGMDRD577	BIX01294	2
iGMDRD506	Fedratinib	2
iGMDRD64	Parbendazole	2
iGMDRD60	Quinoclamine	3
iGMDRD474	Avrainvillamide	1
iGMDRD138	PX 12	1
iGMDRD207	Capsaicin	2
iGMDRD52	Rotenone	2
iGMDRD226	ML006	2
iGMDRD318	PAC-1	2
iGMDRD152	179324-69-7	4
iGMDRD61	Kinetin riboside	7
iGMDRD679	Bistramide A	2
iGMDRD280	CYTOCHALASIN B	3
iGMDRD394	BX-795	1
iGMDRD375	GW-405833	2
iGMDRD420	Leucascandrolide A	3
iGMDRD599	Salermide	3
iGMDRD144	NSC95397	2
iGMDRD427	ABT737	2
iGMDRD494	Neopeltolide	2
iGMDRD329	Merck60	2
iGMDRD263	AACOCF3	4
iGMDRD552	AZD-1775	4
iGMDRD42	Vorinostat	4
iGMDRD202	Curcumin	3
iGMDRD121	GMX1778	2
iGMDRD251	ML162	2
iGMDRD5	Tyrphostin AG 1478	4
iGMDRD289	Parthenolide	4
iGMDRD481	Dactolisib	2
iGMDRD698	Neratinib	4
iGMDRD901	ELCPK	2
iGMDRD945	ML214	1
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD511	CHEMBL399379	2
iGMDRD486	Tosedostat	3
iGMDRD330	BRD4132	2
iGMDRD522	ML-030	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIAM1

SITE

DATATYPES

CLASSFICATION

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