Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008].

TIMP metallopeptidase inhibitor 1MIM:305370Ensembl:ENSG00000102265HGNC:HGNC:11820PA36526Xp11.3

GO terms in TIMP1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0002020protease binding
MFIDAGO:0005125cytokine activity
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIBAGO:0008191metalloendopeptidase inhibitor activity
MFIDAGO:0008191metalloendopeptidase inhibitor activity
MFIDAGO:0008270zinc ion binding
MFIDAGO:0030414peptidase inhibitor activity
BPIEAGO:0001775cell activation
BPIEAGO:0002248connective tissue replacement involved in inflammatory response wound healing
BPTASGO:0002576platelet degranulation
BPIDAGO:0008284positive regulation of cell proliferation
BPIBAGO:0009725response to hormone
BPIBAGO:0010033response to organic substance
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0010951negative regulation of endopeptidase activity
BPIDAGO:0010951negative regulation of endopeptidase activity
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0022617extracellular matrix disassembly
BPIBAGO:0034097response to cytokine
BPIEAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043086negative regulation of catalytic activity
BPIEAGO:0043434response to peptide hormone
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIBAGO:0051045negative regulation of membrane protein ectodomain proteolysis
BPIDAGO:0051045negative regulation of membrane protein ectodomain proteolysis
BPIEAGO:0051216cartilage development
BPIMPGO:1901164negative regulation of trophoblast cell migration
BPIDAGO:1905049negative regulation of metallopeptidase activity
BPIMPGO:2001044regulation of integrin-mediated signaling pathway
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIEAGO:0005604basement membrane
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0031093platelet alpha granule lumen
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: TIMP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIMP1

DatabasePathway IDPathway Des.
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1592389Activation of Matrix Metalloproteinases
reactomeR-HSA-168256Immune System
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6783783Interleukin-10 signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8957275Post-translational protein phosphorylation
biocartareckpathwayinhibition of matrix metalloproteinases
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
pidap1_pathwayAP-1 transcription factor network
pidil6_7pathwayIL6-mediated signaling events
wikipathwaysWP129Matrix Metalloproteinases
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4063Interleukin-10 signaling
wikipathwaysWP4066Interleukin-4 and 13 signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIMP1