TIMP1
Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TIMP metallopeptidase inhibitor 1 | MIM:305370 | Ensembl:ENSG00000102265 | HGNC:HGNC:11820 | PA36526 | Xp11.3 |
GO terms in TIMP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0002020 | protease binding |
| MF | IDA | GO:0005125 | cytokine activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008083 | growth factor activity |
| MF | IBA | GO:0008191 | metalloendopeptidase inhibitor activity |
| MF | IDA | GO:0008191 | metalloendopeptidase inhibitor activity |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0030414 | peptidase inhibitor activity |
| BP | IEA | GO:0001775 | cell activation |
| BP | IEA | GO:0002248 | connective tissue replacement involved in inflammatory response wound healing |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | IEA | GO:0007568 | aging |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009725 | response to hormone |
| BP | IBA | GO:0010033 | response to organic substance |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IDA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043086 | negative regulation of catalytic activity |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IBA | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| BP | IDA | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IMP | GO:1901164 | negative regulation of trophoblast cell migration |
| BP | IDA | GO:1905049 | negative regulation of metallopeptidase activity |
| BP | IMP | GO:2001044 | regulation of integrin-mediated signaling pathway |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005604 | basement membrane |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: TIMP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TIMP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| biocarta | reckpathway | inhibition of matrix metalloproteinases |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | il6_7pathway | IL6-mediated signaling events |
| wikipathways | WP129 | Matrix Metalloproteinases |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD101 | Fulvestrant | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TIMP1
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