TKT
Summary: This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nametransketolase OMIM IDMIM:606781 Ensembl IDEnsembl:ENSG00000163931 HGNC IDHGNC:HGNC:11834 PHARMGKB IDPA36537 Map Location3p21.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in TKT
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005777 | peroxisome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | HDA | GO:0031982 | vesicle |
Gene expression in normal tissue: TKT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TKT
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| humancyc | NONOXIPENT-PWY | pentose phosphate pathway (non-oxidative branch) |
| humancyc | PENTOSE-P-PWY | pentose phosphate pathway |
| kegg | hsa00030 | Pentose phosphate pathway - Homo sapiens (human) |
| smpdb | SMP00031 | Pentose Phosphate Pathway |
| smpdb | SMP00518 | Glucose-6-phosphate dehydrogenase deficiency |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TKT
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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