CLDN5


Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
claudin 5MIM:602101Ensembl:ENSG00000184113HGNC:HGNC:2047PA2657322q11.21

GO terms in CLDN5


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005198structural molecule activity
MFISSGO:0042802identical protein binding
BPTASGO:0003151outflow tract morphogenesis
BPIMPGO:0007043cell-cell junction assembly
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007612learning
BPISSGO:0016338calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
BPTASGO:0060021roof of mouth development
BPTASGO:0060325face morphogenesis
BPIMPGO:1903142positive regulation of establishment of endothelial barrier
BPTASGO:2000810regulation of bicellular tight junction assembly
CCIDAGO:0005886plasma membrane
CCIDAGO:0005911cell-cell junction
CCIDAGO:0005923bicellular tight junction
CCISSGO:0005923bicellular tight junction
CCNASGO:0016021integral component of membrane
CCTASGO:0016021integral component of membrane
CCIDAGO:0016327apicolateral plasma membrane
CCTASGO:0030054cell junction
CCIDAGO:0030864cortical actin cytoskeleton

Gene expression in normal tissue: CLDN5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CLDN5


DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
wikipathwaysWP410Exercise-induced Circadian Regulation
wikipathwaysWP4105Transcriptional regulation by RUNX1
wikipathwaysWP4239EMT transition in Colorectal Cancer
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-420029Tight junction interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-446728Cell junction organization
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8935964RUNX1 regulates expression of components of tight junctions

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CLDN5

​​​​