NR2C2


Summary: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor subfamily 2 group C member 2MIM:601426Ensembl:ENSG00000177463HGNC:HGNC:7972PA317553p25.1

GO terms in NR2C2


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPIEAGO:0007283spermatogenesis
BPTASGO:0007399nervous system development
BPIEAGO:0030154cell differentiation
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFICGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFTASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFTASGO:0038023signaling receptor activity
MFIDAGO:0043565sequence-specific DNA binding
MFIDAGO:0046982protein heterodimerization activity

Gene expression in normal tissue: NR2C2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NR2C2


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP3668Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
wikipathwaysWP4239EMT transition in Colorectal Cancer
pidar_tf_pathwayRegulation of Androgen receptor activity
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_TNFalphaTNFalpha
biocartap38mapkpathwayp38 mapk signaling pathway
biocartatgfbpathwaytgf beta signaling pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NR2C2

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