TRIP6
Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602933 Ensembl IDEnsembl:ENSG00000087077 HGNC IDHGNC:HGNC:12311 PHARMGKB IDPA36989 Map Location7q22.1 | |||||
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in TRIP6
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | NAS | GO:0048041 | focal adhesion assembly |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: TRIP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIP6
Loading, please wait...
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
Showing 1 to 4 of 4 rows
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIP6
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.