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PHLDA2

Summary: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namepleckstrin homology like domain family A member 2 OMIM IDMIM:602131 Ensembl IDEnsembl:ENSG00000181649 HGNC IDHGNC:HGNC:12385 PHARMGKB IDPA37053 Map Location11p15.4

Gene Categories:

HORMONE ACTIVITY

GO terms in PHLDA2

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0001890	placenta development
BP	TAS	GO:0006915	apoptotic process
BP	IEA	GO:0009887	animal organ morphogenesis
BP	IEA	GO:0010468	regulation of gene expression
BP	IEA	GO:0030334	regulation of cell migration
BP	IEA	GO:0060721	regulation of spongiotrophoblast cell proliferation

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Gene expression in normal tissue: PHLDA2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PHLDA2

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Database	Pathway ID	Pathway Des.
No matching records found

Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PHLDA2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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