Summary: This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].

complement C5MIM:120900Ensembl:ENSG00000106804HGNC:HGNC:1331PA259119q33.2

GO terms in C5

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004866endopeptidase inhibitor activity
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFTASGO:0008009chemokine activity
BPTASGO:0000187activation of MAPK activity
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0006954inflammatory response
BPIEAGO:0006957complement activation, alternative pathway
BPIEAGO:0006958complement activation, classical pathway
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0010575positive regulation of vascular endothelial growth factor production
BPIDAGO:0010760negative regulation of macrophage chemotaxis
BPIEAGO:0010951negative regulation of endopeptidase activity
BPTASGO:0030449regulation of complement activation
BPIEAGO:0045766positive regulation of angiogenesis
BPIEAGO:0060326cell chemotaxis
BPIDAGO:0090197positive regulation of chemokine secretion
CCTASGO:0005576extracellular region
CCIDAGO:0005579membrane attack complex
CCTASGO:0005615extracellular space
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: C5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in C5

DatabasePathway IDPathway Des.
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2806Human Complement System
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP545Complement Activation
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
biocartaalternativepathwayalternative complement pathway
biocartaclassicpathwayclassical complement pathway
biocartalectinpathwaylectin induced complement pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166658Complement cascade
reactomeR-HSA-166665Terminal pathway of complement
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-174577Activation of C3 and C5
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-977606Regulation of Complement cascade

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in C5