UBA52
Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitin A-52 residue ribosomal protein fusion product 1 | MIM:191321 | Ensembl:ENSG00000221983 | HGNC:HGNC:12458 | PA37108 | 19p13.11 |
GO terms in UBA52
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003735 | structural constituent of ribosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031386 | protein tag |
| MF | IBA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0070628 | proteasome binding |
| CC | HDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005840 | ribosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IBA | GO:0015935 | small ribosomal subunit |
| CC | IBA | GO:0022627 | cytosolic small ribosomal subunit |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | HDA | GO:0031982 | vesicle |
| CC | IEA | GO:0043657 | host cell |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0000209 | protein polyubiquitination |
| BP | TAS | GO:0000715 | nucleotide-excision repair, DNA damage recognition |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | TAS | GO:0006413 | translational initiation |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | TAS | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane |
| BP | TAS | GO:0006625 | protein targeting to peroxisome |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016197 | endosomal transport |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0019058 | viral life cycle |
| BP | TAS | GO:0019068 | virion assembly |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0019941 | modification-dependent protein catabolic process |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | TAS | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | TAS | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway |
| BP | TAS | GO:0036297 | interstrand cross-link repair |
| BP | TAS | GO:0042276 | error-prone translesion synthesis |
| BP | TAS | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0051403 | stress-activated MAPK cascade |
| BP | TAS | GO:0055085 | transmembrane transport |
| BP | TAS | GO:0061024 | membrane organization |
| BP | TAS | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | TAS | GO:0070911 | global genome nucleotide-excision repair |
| BP | TAS | GO:0070987 | error-free translesion synthesis |
| BP | TAS | GO:0075733 | intracellular transport of virus |
Gene expression in normal tissue: UBA52
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBA52
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP466 | DNA Replication |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| kegg | hsa03010 | Ribosome - Homo sapiens (human) |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-110312 | Translesion synthesis by REV1 |
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex |
| reactome | R-HSA-110320 | Translesion Synthesis by POLH |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1234174 | Regulation of Hypoxia-inducible Factor (HIF) by oxygen |
| reactome | R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1253288 | Downregulation of ERBB4 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-156842 | Eukaryotic Translation Elongation |
| reactome | R-HSA-156902 | Peptide chain elongation |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162588 | Budding and maturation of HIV virion |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-169911 | Regulation of Apoptosis |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B |
| reactome | R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C |
| reactome | R-HSA-174113 | SCF-beta-TrCP mediated degradation of Emi1 |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| reactome | R-HSA-174490 | Membrane binding and targetting of GAG proteins |
| reactome | R-HSA-174495 | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| reactome | R-HSA-175474 | Assembly Of The HIV Virion |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A |
| reactome | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-180534 | Vpu mediated degradation of CD4 |
| reactome | R-HSA-180585 | Vif-mediated degradation of APOBEC3G |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-192823 | Viral mRNA Translation |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-205043 | NRIF signals cell death from the nucleus |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209560 | NF-kB is activated and signals survival |
| reactome | R-HSA-211733 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2173795 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-2262749 | Cellular response to hypoxia |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-2408557 | Selenocysteine synthesis |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559585 | Oncogene Induced Senescence |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA |
| reactome | R-HSA-3229121 | Glycogen storage diseases |
| reactome | R-HSA-3322077 | Glycogen synthesis |
| reactome | R-HSA-349425 | Autodegradation of the E3 ubiquitin ligase COP1 |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-3785653 | Myoclonic epilepsy of Lafora |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445989 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450321 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| reactome | R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-4608870 | Asymmetric localization of PCP proteins |
| reactome | R-HSA-4641257 | Degradation of AXIN |
| reactome | R-HSA-4641258 | Degradation of DVL |
| reactome | R-HSA-4641263 | Regulation of FZD by ubiquitination |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5205647 | Mitophagy |
| reactome | R-HSA-5205685 | Pink/Parkin Mediated Mitophagy |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5358346 | Hedgehog ligand biogenesis |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5362768 | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |
| reactome | R-HSA-5387390 | Hh mutants abrogate ligand secretion |
| reactome | R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5610780 | Degradation of GLI1 by the proteasome |
| reactome | R-HSA-5610783 | Degradation of GLI2 by the proteasome |
| reactome | R-HSA-5610785 | GLI3 is processed to GLI3R by the proteasome |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5610787 | Hedgehog 'off' state |
| reactome | R-HSA-5619084 | ABC transporter disorders |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655862 | Translesion synthesis by POLK |
| reactome | R-HSA-5656121 | Translesion synthesis by POLI |
| reactome | R-HSA-5656169 | Termination of translesion DNA synthesis |
| reactome | R-HSA-5658442 | Regulation of RAS by GAPs |
| reactome | R-HSA-5663084 | Diseases of carbohydrate metabolism |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5668914 | Diseases of metabolism |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-5676590 | NIK-->noncanonical NF-kB signaling |
| reactome | R-HSA-5678895 | Defective CFTR causes cystic fibrosis |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689603 | UCH proteinases |
| reactome | R-HSA-5689603 | UCH proteinases |
| reactome | R-HSA-5689877 | Josephin domain DUBs |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-5689901 | Metalloprotease DUBs |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693606 | DNA Double Strand Break Response |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5696394 | DNA Damage Recognition in GG-NER |
| reactome | R-HSA-5696395 | Formation of Incision Complex in GG-NER |
| reactome | R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6783310 | Fanconi Anemia Pathway |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6804760 | Regulation of TP53 Activity through Methylation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-68827 | CDT1 association with the CDC6:ORC:origin complex |
| reactome | R-HSA-68867 | Assembly of the pre-replicative complex |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-68949 | Orc1 removal from chromatin |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69229 | Ubiquitin-dependent degradation of Cyclin D1 |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69541 | Stabilization of p53 |
| reactome | R-HSA-69563 | p53-Dependent G1 DNA Damage Response |
| reactome | R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint |
| reactome | R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| reactome | R-HSA-69610 | p53-Independent DNA Damage Response |
| reactome | R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72689 | Formation of a pool of free 40S subunits |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72764 | Eukaryotic Translation Termination |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73893 | DNA Damage Bypass |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75815 | Ubiquitin-dependent degradation of Cyclin D |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849469 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| reactome | R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8941858 | Regulation of RUNX3 expression and activity |
| reactome | R-HSA-8948747 | Regulation of PTEN localization |
| reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8982491 | Glycogen metabolism |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-901032 | ER Quality Control Compartment (ERQC) |
| reactome | R-HSA-901042 | Calnexin/calreticulin cycle |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-9010553 | Regulation of expression of SLITs and ROBOs |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 |
| reactome | R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-9033241 | Peroxisomal protein import |
| reactome | R-HSA-9033241 | Peroxisomal protein import |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-917729 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| reactome | R-HSA-917937 | Iron uptake and transport |
| reactome | R-HSA-927802 | Nonsense-Mediated Decay (NMD) |
| reactome | R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling |
| reactome | R-HSA-936964 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| reactome | R-HSA-937039 | IRAK1 recruits IKK complex |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937042 | IRAK2 mediated activation of TAK1 complex |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| reactome | R-HSA-9604323 | Negative regulation of NOTCH4 signaling |
| reactome | R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975144 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| reactome | R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| reactome | R-HSA-977225 | Amyloid fiber formation |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983712 | Ion channel transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBA52
CLASSFICATION
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