UBA52


Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ubiquitin A-52 residue ribosomal protein fusion product 1MIM:191321Ensembl:ENSG00000221983HGNC:HGNC:12458PA3710819p13.11

GO terms in UBA52


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003735structural constituent of ribosome
MFIPIGO:0005515protein binding
MFIBAGO:0031386protein tag
MFIBAGO:0031625ubiquitin protein ligase binding
MFIBAGO:0070628proteasome binding
CCHDAGO:0005615extracellular space
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCTASGO:0005741mitochondrial outer membrane
CCHDAGO:0005765lysosomal membrane
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005840ribosome
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0010008endosome membrane
CCIBAGO:0015935small ribosomal subunit
CCIBAGO:0022627cytosolic small ribosomal subunit
CCTASGO:0030666endocytic vesicle membrane
CCHDAGO:0031982vesicle
CCIEAGO:0043657host cell
CCHDAGO:0070062extracellular exosome
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPTASGO:0000187activation of MAPK activity
BPTASGO:0000209protein polyubiquitination
BPTASGO:0000715nucleotide-excision repair, DNA damage recognition
BPTASGO:0002755MyD88-dependent toll-like receptor signaling pathway
BPTASGO:0006283transcription-coupled nucleotide-excision repair
BPTASGO:0006294nucleotide-excision repair, preincision complex assembly
BPTASGO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion
BPTASGO:0006297nucleotide-excision repair, DNA gap filling
BPTASGO:0006413translational initiation
BPTASGO:0006464cellular protein modification process
BPTASGO:0006614SRP-dependent cotranslational protein targeting to membrane
BPTASGO:0006625protein targeting to peroxisome
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPTASGO:0007254JNK cascade
BPTASGO:0016055Wnt signaling pathway
BPTASGO:0016197endosomal transport
BPIBAGO:0016567protein ubiquitination
BPTASGO:0016567protein ubiquitination
BPTASGO:0016579protein deubiquitination
BPTASGO:0019058viral life cycle
BPTASGO:0019068virion assembly
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0019941modification-dependent protein catabolic process
BPTASGO:0019985translesion synthesis
BPTASGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPTASGO:0031145anaphase-promoting complex-dependent catabolic process
BPTASGO:0033683nucleotide-excision repair, DNA incision
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPTASGO:0036297interstrand cross-link repair
BPTASGO:0042276error-prone translesion synthesis
BPTASGO:0042769DNA damage response, detection of DNA damage
BPTASGO:0043065positive regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043488regulation of mRNA stability
BPTASGO:0044267cellular protein metabolic process
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051403stress-activated MAPK cascade
BPTASGO:0055085transmembrane transport
BPTASGO:0061024membrane organization
BPTASGO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia
BPTASGO:0070423nucleotide-binding oligomerization domain containing signaling pathway
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPTASGO:0070911global genome nucleotide-excision repair
BPTASGO:0070987error-free translesion synthesis
BPTASGO:0075733intracellular transport of virus

Gene expression in normal tissue: UBA52

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UBA52


DatabasePathway IDPathway Des.
wikipathwaysWP466DNA Replication
wikipathwaysWP477Cytoplasmic Ribosomal Proteins
kegghsa03010Ribosome - Homo sapiens (human)
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-110312Translesion synthesis by REV1
reactomeR-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
reactomeR-HSA-110314Recognition of DNA damage by PCNA-containing replication complex
reactomeR-HSA-110320Translesion Synthesis by POLH
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactomeR-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1236974ER-Phagosome pathway
reactomeR-HSA-1236975Antigen processing-Cross presentation
reactomeR-HSA-1253288Downregulation of ERBB4 signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1295596Spry regulation of FGF signaling
reactomeR-HSA-1358803Downregulation of ERBB2:ERBB3 signaling
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156827L13a-mediated translational silencing of Ceruloplasmin expression
reactomeR-HSA-156842Eukaryotic Translation Elongation
reactomeR-HSA-156902Peptide chain elongation
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162588Budding and maturation of HIV virion
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-169911Regulation of Apoptosis
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin B
reactomeR-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/C
reactomeR-HSA-174113SCF-beta-TrCP mediated degradation of Emi1
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174154APC/C:Cdc20 mediated degradation of Securin
reactomeR-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
reactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin A
reactomeR-HSA-174490Membrane binding and targetting of GAG proteins
reactomeR-HSA-174495Synthesis And Processing Of GAG, GAGPOL Polyproteins
reactomeR-HSA-175474Assembly Of The HIV Virion
reactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphase
reactomeR-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-179409APC-Cdc20 mediated degradation of Nek2A
reactomeR-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-1799339SRP-dependent cotranslational protein targeting to membrane
reactomeR-HSA-180534Vpu mediated degradation of CD4
reactomeR-HSA-180585Vif-mediated degradation of APOBEC3G
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-192823Viral mRNA Translation
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-205043NRIF signals cell death from the nucleus
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-209560NF-kB is activated and signals survival
reactomeR-HSA-211733Regulation of activated PAK-2p34 by proteasome mediated degradation
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173788Downregulation of TGF-beta receptor signaling
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-2173795Downregulation of SMAD2/3:SMAD4 transcriptional activity
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
reactomeR-HSA-2262749Cellular response to hypoxia
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-2408557Selenocysteine synthesis
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2467813Separation of Sister Chromatids
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in Cancer
reactomeR-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain Mutants
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-2979096NOTCH2 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-3134975Regulation of innate immune responses to cytosolic DNA
reactomeR-HSA-3229121Glycogen storage diseases
reactomeR-HSA-3322077Glycogen synthesis
reactomeR-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-3785653Myoclonic epilepsy of Lafora
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4086400PCP/CE pathway
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
reactomeR-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-4608870Asymmetric localization of PCP proteins
reactomeR-HSA-4641257Degradation of AXIN
reactomeR-HSA-4641258Degradation of DVL
reactomeR-HSA-4641263Regulation of FZD by ubiquitination
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5205647Mitophagy
reactomeR-HSA-5205685Pink/Parkin Mediated Mitophagy
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycle
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5358346Hedgehog ligand biogenesis
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5362768Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
reactomeR-HSA-5387390Hh mutants abrogate ligand secretion
reactomeR-HSA-5607761Dectin-1 mediated noncanonical NF-kB signaling
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5610780Degradation of GLI1 by the proteasome
reactomeR-HSA-5610783Degradation of GLI2 by the proteasome
reactomeR-HSA-5610785GLI3 is processed to GLI3R by the proteasome
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5610787Hedgehog 'off' state
reactomeR-HSA-5619084ABC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655862Translesion synthesis by POLK
reactomeR-HSA-5656121Translesion synthesis by POLI
reactomeR-HSA-5656169Termination of translesion DNA synthesis
reactomeR-HSA-5658442Regulation of RAS by GAPs
reactomeR-HSA-5663084Diseases of carbohydrate metabolism
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-5676590NIK-->noncanonical NF-kB signaling
reactomeR-HSA-5678895Defective CFTR causes cystic fibrosis
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689603UCH proteinases
reactomeR-HSA-5689603UCH proteinases
reactomeR-HSA-5689877Josephin domain DUBs
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-5689896Ovarian tumor domain proteases
reactomeR-HSA-5689901Metalloprotease DUBs
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-5696394DNA Damage Recognition in GG-NER
reactomeR-HSA-5696395Formation of Incision Complex in GG-NER
reactomeR-HSA-5696397Gap-filling DNA repair synthesis and ligation in GG-NER
reactomeR-HSA-5696398Nucleotide Excision Repair
reactomeR-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)
reactomeR-HSA-5696400Dual Incision in GG-NER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6781823Formation of TC-NER Pre-Incision Complex
reactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactomeR-HSA-6782135Dual incision in TC-NER
reactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NER
reactomeR-HSA-6783310Fanconi Anemia Pathway
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6804760Regulation of TP53 Activity through Methylation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6807004Negative regulation of MET activity
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-68827CDT1 association with the CDC6:ORC:origin complex
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68882Mitotic Anaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-68949Orc1 removal from chromatin
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69229Ubiquitin-dependent degradation of Cyclin D1
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69541Stabilization of p53
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
reactomeR-HSA-69610p53-Independent DNA Damage Response
reactomeR-HSA-69613p53-Independent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72689Formation of a pool of free 40S subunits
reactomeR-HSA-72706GTP hydrolysis and joining of the 60S ribosomal subunit
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72764Eukaryotic Translation Termination
reactomeR-HSA-72766Translation
reactomeR-HSA-72766Translation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-73893DNA Damage Bypass
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin D
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849469PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
reactomeR-HSA-8852135Protein ubiquitination
reactomeR-HSA-8852135Protein ubiquitination
reactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpoint
reactomeR-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8863795Downregulation of ERBB2 signaling
reactomeR-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymes
reactomeR-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymes
reactomeR-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteins
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cell
reactomeR-HSA-8876384Listeria monocytogenes entry into host cells
reactomeR-HSA-8876493InlA-mediated entry of Listeria monocytogenes into host cells
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8941858Regulation of RUNX3 expression and activity
reactomeR-HSA-8948747Regulation of PTEN localization
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8982491Glycogen metabolism
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-901032ER Quality Control Compartment (ERQC)
reactomeR-HSA-901042Calnexin/calreticulin cycle
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013973TICAM1-dependent activation of IRF3/IRF7
reactomeR-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complex
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-9033241Peroxisomal protein import
reactomeR-HSA-9033241Peroxisomal protein import
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-917729Endosomal Sorting Complex Required For Transport (ESCRT)
reactomeR-HSA-917937Iron uptake and transport
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-936440Negative regulators of DDX58/IFIH1 signaling
reactomeR-HSA-936964Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
reactomeR-HSA-937039IRAK1 recruits IKK complex
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937042IRAK2 mediated activation of TAK1 complex
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complex
reactomeR-HSA-9604323Negative regulation of NOTCH4 signaling
reactomeR-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975144IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-975956Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
reactomeR-HSA-977225Amyloid fiber formation
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UBA52

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