UBTF
Summary: This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| upstream binding transcription factor | MIM:600673 | Ensembl:ENSG00000108312 | HGNC:HGNC:12511 | PA37158 | 17q21.31 |
GO terms in UBTF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001188 | RNA polymerase I transcriptional preinitiation complex assembly |
| BP | NAS | GO:0006356 | regulation of transcription by RNA polymerase I |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0006360 | transcription by RNA polymerase I |
| BP | TAS | GO:0006361 | transcription initiation from RNA polymerase I promoter |
| BP | TAS | GO:0006363 | termination of RNA polymerase I transcription |
| BP | ISS | GO:0045943 | positive regulation of transcription by RNA polymerase I |
| BP | IDA | GO:1902659 | regulation of glucose mediated signaling pathway |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | ISS | GO:0005730 | nucleolus |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001164 | RNA polymerase I CORE element sequence-specific DNA binding |
| MF | IDA | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0097110 | scaffold protein binding |
Gene expression in normal tissue: UBTF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UBTF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-73728 | RNA Polymerase I Promoter Opening |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73772 | RNA Polymerase I Promoter Escape |
| reactome | R-HSA-73777 | RNA Polymerase I Chain Elongation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| wikipathways | WP2858 | Ectoderm Differentiation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UBTF
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