UCP2
Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| uncoupling protein 2 | MIM:601693 | Ensembl:ENSG00000175567 | HGNC:HGNC:12518 | PA37165 | 11q13.4 |
GO terms in UCP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000303 | response to superoxide |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007568 | aging |
| BP | IBA | GO:0009409 | response to cold |
| BP | IEA | GO:0010942 | positive regulation of cell death |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0034198 | cellular response to amino acid starvation |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | IEA | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0070542 | response to fatty acid |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | TAS | GO:1902600 | proton transmembrane transport |
| BP | IBA | GO:1990542 | mitochondrial transmembrane transport |
| BP | IBA | GO:1990845 | adaptive thermogenesis |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017077 | oxidative phosphorylation uncoupler activity |
Gene expression in normal tissue: UCP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UCP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| reactome | R-HSA-166187 | Mitochondrial Uncoupling Proteins |
| reactome | R-HSA-167826 | The fatty acid cycling model |
| reactome | R-HSA-167827 | The proton buffering model |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| wikipathways | WP111 | Electron Transport Chain |
| wikipathways | WP1541 | Energy Metabolism |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UCP2
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