UGDH


Summary: The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
UDP-glucose 6-dehydrogenaseMIM:603370Ensembl:ENSG00000109814HGNC:HGNC:12525PA371704p14

GO terms in UGDH


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003979UDP-glucose 6-dehydrogenase activity
MFTASGO:0009055electron transfer activity
MFIEAGO:0051287NAD binding
BPIEAGO:0001702gastrulation with mouth forming second
BPTASGO:0006011UDP-glucose metabolic process
BPIBAGO:0006024glycosaminoglycan biosynthetic process
BPTASGO:0006024glycosaminoglycan biosynthetic process
BPIEAGO:0006065UDP-glucuronate biosynthetic process
BPTASGO:0006065UDP-glucuronate biosynthetic process
BPIEAGO:0022900electron transport chain
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: UGDH

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in UGDH


DatabasePathway IDPathway Des.
smpdbSMP00010Nucleotide Sugars Metabolism
smpdbSMP00058Starch and Sucrose Metabolism
smpdbSMP00495Galactosemia II (GALK)
smpdbSMP00496Galactosemia III
smpdbSMP00552Glycogen synthetase deficiency
smpdbSMP00553Glycogenosis, Type III. Cori disease, Debrancher glycogenosis
smpdbSMP00554Glycogenosis, Type IV. Amylopectinosis, Anderson disease
smpdbSMP00555Glycogenosis, Type VI. Hers disease
smpdbSMP00556Mucopolysaccharidosis VI. Sly syndrome
smpdbSMP00557Sucrase-isomaltase deficiency
wikipathwaysWP698Glucuronidation
humancycPWY-4821UDP-D-xylose and UDP-D-glucuronate biosynthesis
kegghsa00040Pentose and glucuronate interconversions - Homo sapiens (human)
kegghsa00053Ascorbate and aldarate metabolism - Homo sapiens (human)
kegghsa00520Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-156580Phase II - Conjugation of compounds
reactomeR-HSA-156588Glucuronidation
reactomeR-HSA-173599Formation of the active cofactor, UDP-glucuronate
reactomeR-HSA-211859Biological oxidations

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in UGDH

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