UTY
Summary: This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | MIM:400009 | Ensembl:ENSG00000183878 | HGNC:HGNC:12638 | PA37263 | Yq11.221 |
Gene Categories:
HISTONE MODIFICATIONGO terms in UTY
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IBA | GO:0031490 | chromatin DNA binding |
| MF | TAS | GO:0032452 | histone demethylase activity |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0051213 | dioxygenase activity |
| MF | IBA | GO:0071558 | histone demethylase activity (H3-K27 specific) |
| MF | IEA | GO:0071558 | histone demethylase activity (H3-K27 specific) |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0044666 | MLL3/4 complex |
| BP | IEA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0071557 | histone H3-K27 demethylation |
Gene expression in normal tissue: UTY
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UTY
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| reactome | R-HSA-3214842 | HDMs demethylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UTY
CLASSFICATION
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