Summary: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011].

vascular endothelial growth factor BMIM:601398Ensembl:ENSG00000173511HGNC:HGNC:12681PA3730311q13.1

GO terms in VEGFB

Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIEAGO:0008201heparin binding
MFIBAGO:0042056chemoattractant activity
MFIEAGO:0042803protein homodimerization activity
MFIBAGO:0043183vascular endothelial growth factor receptor 1 binding
MFIBAGO:0043184vascular endothelial growth factor receptor 2 binding
MFIBAGO:0043185vascular endothelial growth factor receptor 3 binding
MFIEAGO:0046982protein heterodimerization activity
BPIBAGO:0001666response to hypoxia
BPIBAGO:0001934positive regulation of protein phosphorylation
BPIBAGO:0001938positive regulation of endothelial cell proliferation
BPIBAGO:0002040sprouting angiogenesis
BPTASGO:0002576platelet degranulation
BPIEAGO:0006493protein O-linked glycosylation
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0038084vascular endothelial growth factor signaling pathway
BPIEAGO:0042493response to drug
BPIBAGO:0045766positive regulation of angiogenesis
BPIBAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIBAGO:0050930induction of positive chemotaxis
BPIEAGO:0051781positive regulation of cell division
BPIEAGO:0060048cardiac muscle contraction
BPIBAGO:0060754positive regulation of mast cell chemotaxis
BPIEAGO:0060976coronary vasculature development
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCTASGO:0031093platelet alpha granule lumen

Gene expression in normal tissue: VEGFB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VEGFB

DatabasePathway IDPathway Des.
wikipathwaysWP1591Heart Development
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3593miR-148a-miR-31-FIH1-HIF1?-Notch signaling in glioblastoma
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
pidvegf_vegfr_pathwayVEGF and VEGFR signaling network
pidvegfr1_pathwayVEGFR1 specific signals
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pharmgkbPA2032VEGF Signaling Pathway
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194313VEGF ligand-receptor interactions
reactomeR-HSA-195399VEGF binds to VEGFR leading to receptor dimerization
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VEGFB